Heart rate variability regression and risk of sudden unexpected death in epilepsy

Alessio Galli, Federico Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

The exact mechanisms of sudden unexpected death in epilepsy remain elusive, despite there is consensus that SUDEP is associated with severe derangements in the autonomic control to vital functions as breathing and heart rate regulation. Heart rate variability (HRV) has been advocated as biomarker of autonomic control to the heart. Cardiac dysautonomia has been found in diseases where other branches of the autonomous nervous system are damaged, as Parkinson disease and multiple system atrophy. In this perspective, an impaired HRV not only is a risk factor for sudden cardiac death mediated by arrhythmias, but also a potential biomarker for monitoring a progressive decline of the autonomous nervous system. This slope may lead to an acute imbalance of the regulatory pathways of vital functions after seizure and then to SUDEP.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalMedical Hypotheses
Volume99
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Heart rate variability
  • Holter monitoring
  • SUDEP

ASJC Scopus subject areas

  • Medicine(all)

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