Heart to heart with trastuzumab: A review on cardiac toxicity

Serena Di Cosimo

Research output: Contribution to journalArticlepeer-review

Abstract

Trastuzumab is regarded as the foundation of care for HER2-positive breast cancer as it has revolutionized the treatment of this disease across all settings. Although generally well tolerated, patients may develop symptomatic or asymptomatic cardiotoxicity, forcing a discontinuation of treatment, therefore preventing patients from benefiting from maximal disease control. Evolving research supports that trastuzumab-induced cardiotoxicity may be prevented or at least minimized by a number of prophylactic measures, such as identification of patients at risk and close monitoring. Optimized chemotherapy regimens, scheduling and formulations also contribute to minimizing cardiac adverse events. Equally important, if cardiotoxicity develops, medical interventions are now available that facilitate the reintroduction of trastuzumab once normal cardiac function has been restored. Awareness of this still-evolving information may lead to optimal use of trastuzumab, especially in combination regimens, maximizing antitumor benefit, while minimizing risk.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalTargeted Oncology
Volume6
Issue number4
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Breast cancer
  • Cardiotoxicity
  • Trastuzumab

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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