Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells

Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, Susanna Chiocca, Elisabeth Christians, Saadi Khochbin, Caroline Jolly, Claire Vourc'h

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.

Original languageEnglish
Pages (from-to)4976-4984
Number of pages9
JournalMolecular Biology of the Cell
Volume20
Issue number23
DOIs
Publication statusPublished - 2009

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Heat-Shock Response
Acetylation
Histones
Shock
Hot Temperature
Genome
Histone Deacetylases
Chromatin
Transcription Factors

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Fritah, S., Col, E., Boyault, C., Govin, J., Sadoul, K., Chiocca, S., ... Vourc'h, C. (2009). Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. Molecular Biology of the Cell, 20(23), 4976-4984. https://doi.org/10.1091/mbc.E09-04-0295

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. / Fritah, Sabrina; Col, Edwige; Boyault, Cyril; Govin, Jérôme; Sadoul, Karin; Chiocca, Susanna; Christians, Elisabeth; Khochbin, Saadi; Jolly, Caroline; Vourc'h, Claire.

In: Molecular Biology of the Cell, Vol. 20, No. 23, 2009, p. 4976-4984.

Research output: Contribution to journalArticle

Fritah, S, Col, E, Boyault, C, Govin, J, Sadoul, K, Chiocca, S, Christians, E, Khochbin, S, Jolly, C & Vourc'h, C 2009, 'Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells', Molecular Biology of the Cell, vol. 20, no. 23, pp. 4976-4984. https://doi.org/10.1091/mbc.E09-04-0295
Fritah, Sabrina ; Col, Edwige ; Boyault, Cyril ; Govin, Jérôme ; Sadoul, Karin ; Chiocca, Susanna ; Christians, Elisabeth ; Khochbin, Saadi ; Jolly, Caroline ; Vourc'h, Claire. / Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. In: Molecular Biology of the Cell. 2009 ; Vol. 20, No. 23. pp. 4976-4984.
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