Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis

C. Boiocchi, M. C. Monti, C. Osera, G. Mallucci, C. Pistono, O. E. Ferraro, G. Nosari, A. Romani, M. Cuccia, S. Govoni, A. Pascale, C. Montomoli, R. Bergamaschi

Research output: Contribution to journalArticlepeer-review

Abstract

Immune-mediated and neurodegenerative mechanisms are involved in multiple sclerosis (MS). Growing evidences highlight the role of HSP70 genes in the susceptibility of some neurological diseases. In this explorative study we analyzed a polymorphism (i.e. HSP70-hom rs2227956) of the gene HSPA1L, which encodes for the protein hsp70-hom. We sequenced the polymorphism by polymerase chain reaction (PCR), in 191 MS patients and 365 healthy controls. The hsp70-hom protein expression was quantified by western blotting. We reported a strong association between rs2227956 polymorphism and MS risk, which is independent from the association with HSP70-2 rs1061581, and a significant link between hsp70-hom protein expression and MS severity.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalJournal of Neuroimmunology
Volume298
DOIs
Publication statusPublished - Sep 15 2016

Keywords

  • Heat shock protein
  • hsp70-hom
  • MS
  • MSSS
  • Multiple sclerosis
  • rs2227956
  • SNP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)
  • Neurology
  • Clinical Neurology

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