Heat shock protein 72 in cardiac and skeletal muscles during hypertension

G. Gaia, L. Comini, E. Pasini, G. Tomelleri, L. Agnoletti, R. Ferrari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume146
Issue number1
DOIs
Publication statusPublished - May 1995

Fingerprint

HSP72 Heat-Shock Proteins
Cardiomegaly
Hypertrophy
Muscle
Myocardium
Skeletal Muscle
Hypertension
Inbred SHR Rats
Heat-Shock Proteins
Rats
Shock
Fever
Age Groups
Hot Temperature
Aging of materials
Western Blotting
Monoclonal Antibodies
Proteins
Gracilis Muscle

Keywords

  • aging
  • heat shock protein
  • hypertension
  • myocardium
  • skeletal muscle

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Heat shock protein 72 in cardiac and skeletal muscles during hypertension. / Gaia, G.; Comini, L.; Pasini, E.; Tomelleri, G.; Agnoletti, L.; Ferrari, R.

In: Molecular and Cellular Biochemistry, Vol. 146, No. 1, 05.1995, p. 1-6.

Research output: Contribution to journalArticle

Gaia, G. ; Comini, L. ; Pasini, E. ; Tomelleri, G. ; Agnoletti, L. ; Ferrari, R. / Heat shock protein 72 in cardiac and skeletal muscles during hypertension. In: Molecular and Cellular Biochemistry. 1995 ; Vol. 146, No. 1. pp. 1-6.
@article{ab074a93f336465fb6ec1ae6e7609ebb,
title = "Heat shock protein 72 in cardiac and skeletal muscles during hypertension",
abstract = "In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7{\%} vs 88.3 ±8.5{\%}, p",
keywords = "aging, heat shock protein, hypertension, myocardium, skeletal muscle",
author = "G. Gaia and L. Comini and E. Pasini and G. Tomelleri and L. Agnoletti and R. Ferrari",
year = "1995",
month = "5",
doi = "10.1007/BF00926874",
language = "English",
volume = "146",
pages = "1--6",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Heat shock protein 72 in cardiac and skeletal muscles during hypertension

AU - Gaia, G.

AU - Comini, L.

AU - Pasini, E.

AU - Tomelleri, G.

AU - Agnoletti, L.

AU - Ferrari, R.

PY - 1995/5

Y1 - 1995/5

N2 - In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p

AB - In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p

KW - aging

KW - heat shock protein

KW - hypertension

KW - myocardium

KW - skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=0029003707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029003707&partnerID=8YFLogxK

U2 - 10.1007/BF00926874

DO - 10.1007/BF00926874

M3 - Article

C2 - 7651371

AN - SCOPUS:0029003707

VL - 146

SP - 1

EP - 6

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1

ER -