Abstract
In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 146 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 1995 |
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Keywords
- aging
- heat shock protein
- hypertension
- myocardium
- skeletal muscle
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Clinical Biochemistry
- Cell Biology
Cite this
Heat shock protein 72 in cardiac and skeletal muscles during hypertension. / Gaia, G.; Comini, L.; Pasini, E.; Tomelleri, G.; Agnoletti, L.; Ferrari, R.
In: Molecular and Cellular Biochemistry, Vol. 146, No. 1, 05.1995, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heat shock protein 72 in cardiac and skeletal muscles during hypertension
AU - Gaia, G.
AU - Comini, L.
AU - Pasini, E.
AU - Tomelleri, G.
AU - Agnoletti, L.
AU - Ferrari, R.
PY - 1995/5
Y1 - 1995/5
N2 - In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p
AB - In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p
KW - aging
KW - heat shock protein
KW - hypertension
KW - myocardium
KW - skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=0029003707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029003707&partnerID=8YFLogxK
U2 - 10.1007/BF00926874
DO - 10.1007/BF00926874
M3 - Article
C2 - 7651371
AN - SCOPUS:0029003707
VL - 146
SP - 1
EP - 6
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 1
ER -