Heat shock protein 72 in cardiac and skeletal muscles during hypertension

G. Gaia, L. Comini, E. Pasini, G. Tomelleri, L. Agnoletti, R. Ferrari

Research output: Contribution to journalArticle

Abstract

In order to elucidate the relationship between hypertension and hypertrophy in the production of heat shock proteins, we studied the induction of the HSP72 synthesis by the heart and gracilis muscles of normo (WKY) and hypertensive (SHR) rats subjected to hyperthermia (42°C±0.5 for 15 min). Two age groups were investigated in each strain: young (2 months, with developing cardiac hypertrophy) and old (18 months, with fully developed chronic cardiac hypertrophy). The gracilis muscle never developed hypertrophy, independently of hypertension or aging. 72 kDa inducible protein was determined by Western blot analysis using a specific monoclonal antibody. We also used a commercial standard, loaded on each blot, to quantitate densitometrically the signal. The heart of young SHR responds to heat shock more than their normotensive age-matched control (298.8±24.7% vs 88.3 ±8.5%, p

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume146
Issue number1
DOIs
Publication statusPublished - May 1995

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Keywords

  • aging
  • heat shock protein
  • hypertension
  • myocardium
  • skeletal muscle

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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