Heat shock protein-90, IL-6 and IL-10 in bladder cancer

M. R. Cardillo, P. Sale, F. Di Silverio

Research output: Contribution to journalArticlepeer-review

Abstract

The progression of transitional-cell carcinomas of the bladder is associated with changes in general and local immune status. To understand the factors involved in the progression of transitional cell carcinoma and in the maintenance of an efficient anti-tumoural response, in this study we investigated by immunohistochemistry expression of HSP-90, IL-6 and IL-10 proteins in 56 surgical specimens obtained from superficial and deeply invasive bladder carcinomas. Of the 56 bladder carcinoma 52 (92.9%) expressed HSP-90, 48 (85.7%) IL-6 and 45 (80.3%) IL-10. High-grade and muscle-invasive tumours contained significantly higher levels of HSP-90 and IL-6 antibodies than low-grade and superficial tumours (p

Original languageEnglish
Pages (from-to)4579-4583
Number of pages5
JournalAnticancer Research
Volume20
Issue number6 B
Publication statusPublished - 2000

Keywords

  • Bladder cancer
  • HSP-90
  • IL-10
  • IL-6
  • Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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