Heat shock proteins in human cancer

Cecilia Sarto, Pierre Alain Binz, Paolo Mocarelli

Research output: Contribution to journalArticlepeer-review


The heat shock proteins (hsp) are ubiquitous molecules induced in cells exposed to sublethal heat shock, present in all living cells, and highly conserved during evolution. Their function is to protect cells from environmental stress damage by binding to partially denatured proteins, dissociating protein aggregates, to regulate the correct folding, and to cooperate in transporting newly synthesized polypeptides to the target organelles. The molecular chaperones are involved in numerous diseases, including cancer, revealing changes of expression. In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies.

Original languageEnglish
Pages (from-to)1218-1226
Number of pages9
Issue number6
Publication statusPublished - 2000


  • Cancer
  • Heat shock proteins
  • Post-translational modification
  • Review
  • Two-dimensional electrophoresis

ASJC Scopus subject areas

  • Clinical Biochemistry


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