TY - JOUR
T1 - Heat shock proteins in human cancer
AU - Sarto, Cecilia
AU - Binz, Pierre Alain
AU - Mocarelli, Paolo
PY - 2000
Y1 - 2000
N2 - The heat shock proteins (hsp) are ubiquitous molecules induced in cells exposed to sublethal heat shock, present in all living cells, and highly conserved during evolution. Their function is to protect cells from environmental stress damage by binding to partially denatured proteins, dissociating protein aggregates, to regulate the correct folding, and to cooperate in transporting newly synthesized polypeptides to the target organelles. The molecular chaperones are involved in numerous diseases, including cancer, revealing changes of expression. In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies.
AB - The heat shock proteins (hsp) are ubiquitous molecules induced in cells exposed to sublethal heat shock, present in all living cells, and highly conserved during evolution. Their function is to protect cells from environmental stress damage by binding to partially denatured proteins, dissociating protein aggregates, to regulate the correct folding, and to cooperate in transporting newly synthesized polypeptides to the target organelles. The molecular chaperones are involved in numerous diseases, including cancer, revealing changes of expression. In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies.
KW - Cancer
KW - Heat shock proteins
KW - Post-translational modification
KW - Review
KW - Two-dimensional electrophoresis
UR - http://www.scopus.com/inward/record.url?scp=0034057881&partnerID=8YFLogxK
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U2 - 10.1002/(SICI)1522-2683(20000401)21:6<1218::AID-ELPS1218>3.0.CO;2-H
DO - 10.1002/(SICI)1522-2683(20000401)21:6<1218::AID-ELPS1218>3.0.CO;2-H
M3 - Article
C2 - 10786894
AN - SCOPUS:0034057881
VL - 21
SP - 1218
EP - 1226
JO - Electrophoresis
JF - Electrophoresis
SN - 0173-0835
IS - 6
ER -