Heat shock proteins in thyroid malignancies: Potential therapeutic targets for poorly-differentiated and anaplastic tumours? Molecular and Cellular Endocrinology

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Abstract

Thyroid cancer is the most common endocrine malignancy, with well-differentiated subtypes characterized by an excellent prognosis due to their optimal sensitivity to standard therapies whereas poorly differentiated and anaplastic tumours by chemo/radio-resistance and unfavourable outcome. Heat Shock Proteins (HSPs) are molecular chaperones overexpressed in thyroid malignancies and involved in crucial functions responsible for thyroid carcinogenesis, as protection from apoptosis, drug resistance and cell migration. Thus, HSPs inhibitors have been proposed as novel therapeutic agents in thyroid cancer to revert molecular mechanisms of tumour progression. In this review, we report an overview on the biological role of HSPs, and specifically HSP90s, in thyroid cancer and their potential involvement as biomarkers. We discuss the rationale to evaluate HSPs inhibitors as innovative anticancer agents in specific subtypes of thyroid cancer characterized by poor response to therapies with the objective to target single family chaperones to reduce, simultaneously, the expression/stability of multiple client proteins. © 2019 Elsevier B.V.
Original languageEnglish
JournalMol. Cell. Endocrinol.
Volume502
DOIs
Publication statusPublished - 2020

Keywords

  • Chemoresistance
  • Drug target
  • Heat shock protein
  • Thyroid cancer
  • 2 amino 6 chloro 9 [(4 methoxy 3,5 dimethyl 2 pyridinyl)methyl]purine
  • 4 [[2 carbamoyl 5 (4,5,6,7 tetrahydro 6,6 dimethyl 4 oxo 3 (trifluoromethyl) 1h indazol 1 yl)phenyl]amino]cyclohexyl glycinate
  • antineoplastic agent
  • btimnp d 004
  • ganetespib
  • geldanamycin
  • heat shock protein
  • heat shock protein 27
  • heat shock protein 70
  • heat shock protein 90
  • heat shock protein 90 inhibitor
  • herbimycin A
  • knk 437
  • ku 711
  • luminespib
  • nz 28
  • quercetin
  • radicicol
  • tanespimycin
  • triptolide
  • tumor marker
  • tumor necrosis factor receptor
  • tumor necrosis factor receptor associated protein 1
  • unclassified drug
  • ver 155008
  • wga ta
  • anaplastic thyroid carcinoma
  • apoptosis
  • cell invasion
  • cell migration
  • cell proliferation
  • cytotoxicity
  • differentiated thyroid cancer
  • drug targeting
  • human
  • nonhuman
  • pathogenesis
  • priority journal
  • protein expression
  • protein function
  • protein stability
  • Review
  • signal transduction
  • thyroid cancer
  • drug effect
  • drug resistance
  • genetics
  • metabolism
  • molecularly targeted therapy
  • thyroid tumor
  • upregulation
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Drug Resistance, Neoplasm
  • Heat-Shock Proteins
  • Humans
  • Molecular Targeted Therapy
  • Thyroid Neoplasms
  • Up-Regulation

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