Heat stress limits infarct size in the isolated perfused rabbit heart

D. M. Walker, E. Pasini, S. Kucukoglu, M. S. Marber, E. Iliodromitis, R. Ferrari, D. M. Yellon

Research output: Contribution to journalArticlepeer-review


Objective: Heat stress, with the expression of heat stress proteins, has been shown to protect the rabbit heart in vitro against global ischaemia/reperfusion injury, though no benefit is apparent in an in vivo rabbit model of infarct size. The aim of this study was therefore to investigate this discrepancy and to discover whether heating itself has any effect which could negate the protection derived from myocardial stress protein synthesis. Methods: (1) To ascertain whether heat stress could limit infarct size in the absence of blood, isolated buffer perfused hearts, with or without prior heat stress, were subjected to 45 min of regional ischaemia and 120 min reperfusion, and the resulting infarct size was expressed as a percentage of the risk area (I/R%). (2) The observations were repeated in an isolated blood perfused heart model in which a support rabbit (heat stressed or control) was used to perfuse the isolated heart. Results: In the buffer perfused heart, prior heat stress reduced I/R from 70.8(SEM 4.4)%, n=10, in controls to 51.5(5.7)%, n=12 (p

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalCardiovascular Research
Issue number6
Publication statusPublished - 1993


  • heat shock proteins
  • heat stress
  • myocardial infarct size

ASJC Scopus subject areas

  • Physiology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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