Heavy metals in human amniotic fluid: A pilot study

D. Caserta, A. Mantovani, F. Ciardo, A. Fazi, M. Baldi, M. T. Sessa, C. la Rocca, A. Ronchi, M. Moscarini, C. Minoia

Research output: Contribution to journalArticle

Abstract

Objective: Many heavy metals are essential nutrients for a healthy life. However, significant evidence supports prolonged prenatal exposure as a risk factor for several adverse health effects. The aim of this study is to evaluate the presence of heavy metals in human amniotic fluid (AF) to demonstrate that there is an early fetal in utero exposure. Methods: The concentrations of a variety of heavy metals, including Be, Ag, Ba, Pb, U, Hg, Sr, Cu, Mn, V, Pd, Sn, Sb, Te, Pt, Sc, Tl, Ni, As, Co, Zn and Se, were measured in 25 AF samples obtained from amniocentesis between 15 and 18 weeks of gestational, after informed consent. Results: Be, Ag, Ba, Pb, U, Cu, Sr, Mn, V, Sn, Te, Pt, As, Tl, Sb, Co, Se and Zn concentrations were detected in measurable amounts in second trimester AF. Mg levels are elevated in all samples. Pd, Ni, Sc and Hg concentrations are below the detection limits in all samples. Conclusion: This study demonstrates that heavy metals pass into and accumulate in AF from a very early stage of gestation. Other studies are needed to evaluate the long-term health effects of this early exposure.

Original languageEnglish
Pages (from-to)792-796
Number of pages5
JournalPrenatal Diagnosis
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Amniotic fluid
  • Environment
  • Heavy metals
  • Human health
  • Prenatal exposure

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

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  • Cite this

    Caserta, D., Mantovani, A., Ciardo, F., Fazi, A., Baldi, M., Sessa, M. T., la Rocca, C., Ronchi, A., Moscarini, M., & Minoia, C. (2011). Heavy metals in human amniotic fluid: A pilot study. Prenatal Diagnosis, 31(8), 792-796. https://doi.org/10.1002/pd.2768