Hedgehog signaling during expansion of human pancreatic islet-derived precursors

Rita Gallo, Fabio Arturo Grieco, Lorella Marselli, Elisabetta Ferretti, Alberto Gulino, Piero Marchetti, Francesco Dotta

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A detailed understanding of the molecular process involved in the proliferation of pancreatic precursor cells would provide key elements for developing new therapeutic strategies to cure type 1 diabetes. In the present study we investigated the potential involvement of hedgehog signaling in proliferating human pancreatic islet-derived mesenchymal (hPIDM) cells, a population of cells that can be successfully expanded and induced to differentiate into an insulin-secreting phenotype. Here we report that in these precursor cells a hedgehog signaling pathway is activated, as shown by Gli1 expression, and that a dose-dependent inhibition of such a pathway by cyclopamine results in a significant reduction of cell proliferation.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages3
Publication statusPublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Diabetes
  • Hedgehog signaling
  • Precursor cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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