Abstract
A detailed understanding of the molecular process involved in the proliferation of pancreatic precursor cells would provide key elements for developing new therapeutic strategies to cure type 1 diabetes. In the present study we investigated the potential involvement of hedgehog signaling in proliferating human pancreatic islet-derived mesenchymal (hPIDM) cells, a population of cells that can be successfully expanded and induced to differentiate into an insulin-secreting phenotype. Here we report that in these precursor cells a hedgehog signaling pathway is activated, as shown by Gli1 expression, and that a dose-dependent inhibition of such a pathway by cyclopamine results in a significant reduction of cell proliferation.
| Original language | English |
|---|---|
| Title of host publication | Annals of the New York Academy of Sciences |
| Pages | 43-45 |
| Number of pages | 3 |
| Volume | 1150 |
| DOIs | |
| Publication status | Published - Dec 2008 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1150 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
Keywords
- Diabetes
- Hedgehog signaling
- Precursor cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Fingerprint Dive into the research topics of 'Hedgehog signaling during expansion of human pancreatic islet-derived precursors'. Together they form a unique fingerprint.
Cite this
Gallo, R., Grieco, F. A., Marselli, L., Ferretti, E., Gulino, A., Marchetti, P., & Dotta, F. (2008). Hedgehog signaling during expansion of human pancreatic islet-derived precursors. In Annals of the New York Academy of Sciences (Vol. 1150, pp. 43-45). (Annals of the New York Academy of Sciences; Vol. 1150). https://doi.org/10.1196/annals.1447.024