Hedgehog signaling pathway in neural development and disease

Alberto Gulino, Lucia Di Marcotullio, Elisabetta Ferretti, Enrico De Smaele, Isabella Screpanti

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental and tissue repair processes. Hh signaling pathway is finely tuned in order to maintain physiological cell functions during the development of the nervous system and afterwards. Its deregulation is responsible for a number of diseases (e.g. cancer, neurodegenerative disorders). Recently identified Hh pathway regulatory signals involved in the maintenance of nervous tissue shape and their relevance in human pathology are discussed here.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume32
Issue numberSUPPL 1
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Neural Pathways
Nerve Tissue
Morphogenesis
Neurodegenerative Diseases
Nervous System
Cues
Signal Transduction
Stem Cells
Central Nervous System
Maintenance
Pathology
Brain
Neoplasms

Keywords

  • Brain
  • Cancer
  • Development
  • Hedgehog
  • Numb
  • REN

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Gulino, A., Di Marcotullio, L., Ferretti, E., De Smaele, E., & Screpanti, I. (2007). Hedgehog signaling pathway in neural development and disease. Psychoneuroendocrinology, 32(SUPPL 1). https://doi.org/10.1016/j.psyneuen.2007.03.017

Hedgehog signaling pathway in neural development and disease. / Gulino, Alberto; Di Marcotullio, Lucia; Ferretti, Elisabetta; De Smaele, Enrico; Screpanti, Isabella.

In: Psychoneuroendocrinology, Vol. 32, No. SUPPL 1, 08.2007.

Research output: Contribution to journalArticle

Gulino, A, Di Marcotullio, L, Ferretti, E, De Smaele, E & Screpanti, I 2007, 'Hedgehog signaling pathway in neural development and disease', Psychoneuroendocrinology, vol. 32, no. SUPPL 1. https://doi.org/10.1016/j.psyneuen.2007.03.017
Gulino A, Di Marcotullio L, Ferretti E, De Smaele E, Screpanti I. Hedgehog signaling pathway in neural development and disease. Psychoneuroendocrinology. 2007 Aug;32(SUPPL 1). https://doi.org/10.1016/j.psyneuen.2007.03.017
Gulino, Alberto ; Di Marcotullio, Lucia ; Ferretti, Elisabetta ; De Smaele, Enrico ; Screpanti, Isabella. / Hedgehog signaling pathway in neural development and disease. In: Psychoneuroendocrinology. 2007 ; Vol. 32, No. SUPPL 1.
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