Hedgehog signaling pathway in neural development and disease

Alberto Gulino, Lucia Di Marcotullio, Elisabetta Ferretti, Enrico De Smaele, Isabella Screpanti

Research output: Contribution to journalArticle

Abstract

A number of developmental cues underlie proper brain morphogenesis and plasticity. Hedgehog (Hh) signaling pathway plays a critical role in determining proper embryonic patterning and cell fate determination in the central nervous system. Embryonic and adult neural progenitor cells are mostly responsive to Hh signaling, thereby sustaining developmental and tissue repair processes. Hh signaling pathway is finely tuned in order to maintain physiological cell functions during the development of the nervous system and afterwards. Its deregulation is responsible for a number of diseases (e.g. cancer, neurodegenerative disorders). Recently identified Hh pathway regulatory signals involved in the maintenance of nervous tissue shape and their relevance in human pathology are discussed here.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume32
Issue numberSUPPL 1
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Brain
  • Cancer
  • Development
  • Hedgehog
  • Numb
  • REN

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

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