Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion

A. E. Rigamonti, S. Bini, F. Piscitelli, A. Lauritano, V. Di Marzo, C. Vanetti, F. Agosti, A. De Col, E. Lucchetti, G. Grugni, A. Sartorio

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hedonic and homeostatic hunger represent two different forms of eating: just for pleasure or following energy deprivation, respectively. Consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and some specific endocannabinoids in normal-weight subjects and patients with morbid obesity. To date, the effects of palatable food on these mediators in Prader–Willi syndrome (PWS) are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, cholecystokinin (CCK), peptide YY (PYY), anandamide (AEA), 2-arachidonoyl-glycerol (2-AG), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in eight satiated adult PWS patients after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same macronutrient composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with decreased circulating levels of PYY. An increase in PEA levels was also observed. By contrast, circulating levels of ghrelin, CCK, AEA, 2-AG and OEA did not differ before and after the exposure/ingestion of either chocolate or nonpalatable foods. Hunger and satiety were similar in the hedonic and non-palatable sessions. In conclusion, when motivation to eat is promoted by highly palatable foods, a depressed postprandial PYY secretion is observed in PWS. Although preliminary, these findings seem to hypothesize a possible role of PYY agonists in the management of PWS patients.

Original languageEnglish
Article number1297553
JournalFood and Nutrition Research
Volume61
Issue number1
DOIs
Publication statusPublished - May 2 2017

Fingerprint

peptide YY
Peptide YY
Pleasure
ghrelin
chocolate
hunger
Eating
ingestion
secretion
Food
cholecystokinin
Ghrelin
Hunger
satiety
food consumption
glycerol
Endocannabinoids
energy deprivation
Cholecystokinin
peptides

Keywords

  • CCK
  • Endocannabinoids
  • Ghrelin
  • Hunger
  • Palatable food
  • Prader-Willi syndrome
  • PYY
  • Satiety

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Rigamonti, A. E., Bini, S., Piscitelli, F., Lauritano, A., Di Marzo, V., Vanetti, C., ... Sartorio, A. (2017). Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion. Food and Nutrition Research, 61(1), [1297553]. https://doi.org/10.1080/16546628.2017.1297553

Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion. / Rigamonti, A. E.; Bini, S.; Piscitelli, F.; Lauritano, A.; Di Marzo, V.; Vanetti, C.; Agosti, F.; De Col, A.; Lucchetti, E.; Grugni, G.; Sartorio, A.

In: Food and Nutrition Research, Vol. 61, No. 1, 1297553, 02.05.2017.

Research output: Contribution to journalArticle

Rigamonti, AE, Bini, S, Piscitelli, F, Lauritano, A, Di Marzo, V, Vanetti, C, Agosti, F, De Col, A, Lucchetti, E, Grugni, G & Sartorio, A 2017, 'Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion', Food and Nutrition Research, vol. 61, no. 1, 1297553. https://doi.org/10.1080/16546628.2017.1297553
Rigamonti AE, Bini S, Piscitelli F, Lauritano A, Di Marzo V, Vanetti C et al. Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion. Food and Nutrition Research. 2017 May 2;61(1). 1297553. https://doi.org/10.1080/16546628.2017.1297553
Rigamonti, A. E. ; Bini, S. ; Piscitelli, F. ; Lauritano, A. ; Di Marzo, V. ; Vanetti, C. ; Agosti, F. ; De Col, A. ; Lucchetti, E. ; Grugni, G. ; Sartorio, A. / Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion. In: Food and Nutrition Research. 2017 ; Vol. 61, No. 1.
@article{a33aa357c4a84a0a85b481c917a9bd29,
title = "Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion",
abstract = "Hedonic and homeostatic hunger represent two different forms of eating: just for pleasure or following energy deprivation, respectively. Consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and some specific endocannabinoids in normal-weight subjects and patients with morbid obesity. To date, the effects of palatable food on these mediators in Prader–Willi syndrome (PWS) are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, cholecystokinin (CCK), peptide YY (PYY), anandamide (AEA), 2-arachidonoyl-glycerol (2-AG), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in eight satiated adult PWS patients after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same macronutrient composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with decreased circulating levels of PYY. An increase in PEA levels was also observed. By contrast, circulating levels of ghrelin, CCK, AEA, 2-AG and OEA did not differ before and after the exposure/ingestion of either chocolate or nonpalatable foods. Hunger and satiety were similar in the hedonic and non-palatable sessions. In conclusion, when motivation to eat is promoted by highly palatable foods, a depressed postprandial PYY secretion is observed in PWS. Although preliminary, these findings seem to hypothesize a possible role of PYY agonists in the management of PWS patients.",
keywords = "CCK, Endocannabinoids, Ghrelin, Hunger, Palatable food, Prader-Willi syndrome, PYY, Satiety",
author = "Rigamonti, {A. E.} and S. Bini and F. Piscitelli and A. Lauritano and {Di Marzo}, V. and C. Vanetti and F. Agosti and {De Col}, A. and E. Lucchetti and G. Grugni and A. Sartorio",
year = "2017",
month = "5",
day = "2",
doi = "10.1080/16546628.2017.1297553",
language = "English",
volume = "61",
journal = "Food and Nutrition Research",
issn = "1654-6628",
publisher = "Co-Action Publishing",
number = "1",

}

TY - JOUR

T1 - Hedonic eating in Prader–Willi syndrome is associated with blunted PYY secretion

AU - Rigamonti, A. E.

AU - Bini, S.

AU - Piscitelli, F.

AU - Lauritano, A.

AU - Di Marzo, V.

AU - Vanetti, C.

AU - Agosti, F.

AU - De Col, A.

AU - Lucchetti, E.

AU - Grugni, G.

AU - Sartorio, A.

PY - 2017/5/2

Y1 - 2017/5/2

N2 - Hedonic and homeostatic hunger represent two different forms of eating: just for pleasure or following energy deprivation, respectively. Consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and some specific endocannabinoids in normal-weight subjects and patients with morbid obesity. To date, the effects of palatable food on these mediators in Prader–Willi syndrome (PWS) are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, cholecystokinin (CCK), peptide YY (PYY), anandamide (AEA), 2-arachidonoyl-glycerol (2-AG), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in eight satiated adult PWS patients after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same macronutrient composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with decreased circulating levels of PYY. An increase in PEA levels was also observed. By contrast, circulating levels of ghrelin, CCK, AEA, 2-AG and OEA did not differ before and after the exposure/ingestion of either chocolate or nonpalatable foods. Hunger and satiety were similar in the hedonic and non-palatable sessions. In conclusion, when motivation to eat is promoted by highly palatable foods, a depressed postprandial PYY secretion is observed in PWS. Although preliminary, these findings seem to hypothesize a possible role of PYY agonists in the management of PWS patients.

AB - Hedonic and homeostatic hunger represent two different forms of eating: just for pleasure or following energy deprivation, respectively. Consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and some specific endocannabinoids in normal-weight subjects and patients with morbid obesity. To date, the effects of palatable food on these mediators in Prader–Willi syndrome (PWS) are still unknown. To explore the role of some gastrointestinal orexigenic and anorexigenic peptides and endocannabinoids (and some related congeners) in chocolate consumption, we measured changes in circulating levels of ghrelin, cholecystokinin (CCK), peptide YY (PYY), anandamide (AEA), 2-arachidonoyl-glycerol (2-AG), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) in eight satiated adult PWS patients after consumption of chocolate and, on a separate day, of a non-palatable isocaloric food with the same macronutrient composition. Evaluation of hunger and satiety was also performed by visual analogic scale. The anticipatory phase and the consumption of food for pleasure were associated with decreased circulating levels of PYY. An increase in PEA levels was also observed. By contrast, circulating levels of ghrelin, CCK, AEA, 2-AG and OEA did not differ before and after the exposure/ingestion of either chocolate or nonpalatable foods. Hunger and satiety were similar in the hedonic and non-palatable sessions. In conclusion, when motivation to eat is promoted by highly palatable foods, a depressed postprandial PYY secretion is observed in PWS. Although preliminary, these findings seem to hypothesize a possible role of PYY agonists in the management of PWS patients.

KW - CCK

KW - Endocannabinoids

KW - Ghrelin

KW - Hunger

KW - Palatable food

KW - Prader-Willi syndrome

KW - PYY

KW - Satiety

UR - http://www.scopus.com/inward/record.url?scp=85034565785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034565785&partnerID=8YFLogxK

U2 - 10.1080/16546628.2017.1297553

DO - 10.1080/16546628.2017.1297553

M3 - Article

VL - 61

JO - Food and Nutrition Research

JF - Food and Nutrition Research

SN - 1654-6628

IS - 1

M1 - 1297553

ER -