Hedonic tone and its mood and cognitive correlates in parkinson's disease

Gianfranco Spalletta, Sabrina Fagioli, Giuseppe Meco, Mariangela Pierantozzi, Alessandro Stefani, Valerio Pisani, Carlo Caltagirone, Francesco E. Pontieri, Francesca Assogna

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Anhedonia has been mainly reported as a symptom of depression and cognitive impairment in Parkinson's disease (PD) patients. Here, we investigated whether hedonic tone depends on depression and clarified its relationship with the cognitive performance of PD patients with different mood disorders. Methods In 254 patients, we assessed hedonic tone using the Snaith-Hamilton Pleasure Scale, depression severity using the Beck Depression Inventory, and cognitive performances using the Mental Deterioration Battery. A structural psychiatric interview was used to diagnose major depressive disorder (MDD) and minor depressive disorder (MIND), according to the DSM-IV-TR criteria. Results PD patients with diagnosis of MDD were more anhedonic than those with MIND and those without depressive disorders. Reduced hedonic tone correlated with depression severity in patients with MDD and no depressive disorders. In multivariate models that consider depression severity and cognitive performances together, anhedonia was related to increased depression severity and episodic memory (auditory-verbal learning) impairment, in patients with MDD and with increased depression severity and attention impairment in patients with no depressive disorders. In patients with MIND, anhedonia did not correlate with depression severity or any cognitive performance score. Discussion Our findings suggest that anhedonia is related to depression severity and specific cognitive performances in patients with MDD and with no depressive disorder. By contrast, the reduced hedonic tone in patients with MIND is independent from depression severity and cognition. Thus, anhedonia in PD is a heterogeneous and multidimensional phenomenon and require investigation at different levels.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalDepression and Anxiety
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Pleasure
Parkinson Disease
Depressive Disorder
Depression
Anhedonia
Major Depressive Disorder
Verbal Learning
Episodic Memory
Mood Disorders
Diagnostic and Statistical Manual of Mental Disorders
Cognition
Psychiatry
Interviews

Keywords

  • anhedonia
  • behavioral symptoms
  • cognition
  • depression
  • movement disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Hedonic tone and its mood and cognitive correlates in parkinson's disease. / Spalletta, Gianfranco; Fagioli, Sabrina; Meco, Giuseppe; Pierantozzi, Mariangela; Stefani, Alessandro; Pisani, Valerio; Caltagirone, Carlo; Pontieri, Francesco E.; Assogna, Francesca.

In: Depression and Anxiety, Vol. 30, No. 1, 01.2013, p. 85-91.

Research output: Contribution to journalArticle

Spalletta, Gianfranco ; Fagioli, Sabrina ; Meco, Giuseppe ; Pierantozzi, Mariangela ; Stefani, Alessandro ; Pisani, Valerio ; Caltagirone, Carlo ; Pontieri, Francesco E. ; Assogna, Francesca. / Hedonic tone and its mood and cognitive correlates in parkinson's disease. In: Depression and Anxiety. 2013 ; Vol. 30, No. 1. pp. 85-91.
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