Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer

A cohort study

Rebecca Ritte, Annekatrin Lukanova, Anne Tjønneland, Anja Olsen, Kim Overvad, Sylvie Mesrine, Guy Fagherazzi, Laure Dossus, Birgit Teucher, Karen Steindorf, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote & 24 others José Ramõn Quirõs, Genevieve Buckland, Esther Molina-Montes, María Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Bas Bueno-De-Mesquita, Franzel Van Duijnhoven, Carla H. Van Gils, Petra Hm Peeters, Nick Wareham, Kay Tee Khaw, Timothy J. Key, Ruth C. Travis, Sanda Krum-Hansen, Inger Torhild Gram, Eiliv Lund, Malin Sund, Anne Andersson, Isabelle Romieu, Sabina Rinaldi, Valerie McCormack, Elio Riboli, Rudolf Kaaks

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women. What's new? Adult height and early age at menarche are established risk factors for breast cancer. In this study, the authors examined these factors in relation to the hormone-receptor status of breast tumors, with height divided into leg length vs. sitting height. They found that women who were tall and had an early menarche (≤13 years) had almost double the risk of developing estrogen/progesterone-positive (ER+PR+) tumors. Leg length and early menarche were also associated with increased risk for receptor-negative (ER-PR-) tumors. In addition, the data suggest possible hormonal links that could be specific for postmenopausal women.

Original languageEnglish
Pages (from-to)2619-2629
Number of pages11
JournalInternational Journal of Cancer
Volume132
Issue number11
DOIs
Publication statusPublished - Jun 1 2013

Fingerprint

Menarche
Leg
Cohort Studies
Hormones
Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Neoplasms
Puberty
Proportional Hazards Models
Uncertainty
Progesterone
Estrogens
Confidence Intervals

Keywords

  • breast cancer
  • ER-receptor
  • height
  • leg length
  • menarche
  • PR-receptor
  • sitting height

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ritte, R., Lukanova, A., Tjønneland, A., Olsen, A., Overvad, K., Mesrine, S., ... Kaaks, R. (2013). Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: A cohort study. International Journal of Cancer, 132(11), 2619-2629. https://doi.org/10.1002/ijc.27913

Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer : A cohort study. / Ritte, Rebecca; Lukanova, Annekatrin; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Mesrine, Sylvie; Fagherazzi, Guy; Dossus, Laure; Teucher, Birgit; Steindorf, Karen; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Quirõs, José Ramõn; Buckland, Genevieve; Molina-Montes, Esther; Chirlaque, María Dolores; Ardanaz, Eva; Amiano, Pilar; Bueno-De-Mesquita, Bas; Van Duijnhoven, Franzel; Van Gils, Carla H.; Peeters, Petra Hm; Wareham, Nick; Khaw, Kay Tee; Key, Timothy J.; Travis, Ruth C.; Krum-Hansen, Sanda; Gram, Inger Torhild; Lund, Eiliv; Sund, Malin; Andersson, Anne; Romieu, Isabelle; Rinaldi, Sabina; McCormack, Valerie; Riboli, Elio; Kaaks, Rudolf.

In: International Journal of Cancer, Vol. 132, No. 11, 01.06.2013, p. 2619-2629.

Research output: Contribution to journalArticle

Ritte, R, Lukanova, A, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Fagherazzi, G, Dossus, L, Teucher, B, Steindorf, K, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Sacerdote, C, Quirõs, JR, Buckland, G, Molina-Montes, E, Chirlaque, MD, Ardanaz, E, Amiano, P, Bueno-De-Mesquita, B, Van Duijnhoven, F, Van Gils, CH, Peeters, PH, Wareham, N, Khaw, KT, Key, TJ, Travis, RC, Krum-Hansen, S, Gram, IT, Lund, E, Sund, M, Andersson, A, Romieu, I, Rinaldi, S, McCormack, V, Riboli, E & Kaaks, R 2013, 'Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: A cohort study', International Journal of Cancer, vol. 132, no. 11, pp. 2619-2629. https://doi.org/10.1002/ijc.27913
Ritte, Rebecca ; Lukanova, Annekatrin ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Mesrine, Sylvie ; Fagherazzi, Guy ; Dossus, Laure ; Teucher, Birgit ; Steindorf, Karen ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Grioni, Sara ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Quirõs, José Ramõn ; Buckland, Genevieve ; Molina-Montes, Esther ; Chirlaque, María Dolores ; Ardanaz, Eva ; Amiano, Pilar ; Bueno-De-Mesquita, Bas ; Van Duijnhoven, Franzel ; Van Gils, Carla H. ; Peeters, Petra Hm ; Wareham, Nick ; Khaw, Kay Tee ; Key, Timothy J. ; Travis, Ruth C. ; Krum-Hansen, Sanda ; Gram, Inger Torhild ; Lund, Eiliv ; Sund, Malin ; Andersson, Anne ; Romieu, Isabelle ; Rinaldi, Sabina ; McCormack, Valerie ; Riboli, Elio ; Kaaks, Rudolf. / Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer : A cohort study. In: International Journal of Cancer. 2013 ; Vol. 132, No. 11. pp. 2619-2629.
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abstract = "Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95{\%} confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women. What's new? Adult height and early age at menarche are established risk factors for breast cancer. In this study, the authors examined these factors in relation to the hormone-receptor status of breast tumors, with height divided into leg length vs. sitting height. They found that women who were tall and had an early menarche (≤13 years) had almost double the risk of developing estrogen/progesterone-positive (ER+PR+) tumors. Leg length and early menarche were also associated with increased risk for receptor-negative (ER-PR-) tumors. In addition, the data suggest possible hormonal links that could be specific for postmenopausal women.",
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T1 - Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer

T2 - A cohort study

AU - Ritte, Rebecca

AU - Lukanova, Annekatrin

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Mesrine, Sylvie

AU - Fagherazzi, Guy

AU - Dossus, Laure

AU - Teucher, Birgit

AU - Steindorf, Karen

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Grioni, Sara

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Quirõs, José Ramõn

AU - Buckland, Genevieve

AU - Molina-Montes, Esther

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Bueno-De-Mesquita, Bas

AU - Van Duijnhoven, Franzel

AU - Van Gils, Carla H.

AU - Peeters, Petra Hm

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Krum-Hansen, Sanda

AU - Gram, Inger Torhild

AU - Lund, Eiliv

AU - Sund, Malin

AU - Andersson, Anne

AU - Romieu, Isabelle

AU - Rinaldi, Sabina

AU - McCormack, Valerie

AU - Riboli, Elio

AU - Kaaks, Rudolf

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women. What's new? Adult height and early age at menarche are established risk factors for breast cancer. In this study, the authors examined these factors in relation to the hormone-receptor status of breast tumors, with height divided into leg length vs. sitting height. They found that women who were tall and had an early menarche (≤13 years) had almost double the risk of developing estrogen/progesterone-positive (ER+PR+) tumors. Leg length and early menarche were also associated with increased risk for receptor-negative (ER-PR-) tumors. In addition, the data suggest possible hormonal links that could be specific for postmenopausal women.

AB - Associations of breast cancer overall with indicators of exposures during puberty are reasonably well characterized; however, uncertainty remains regarding the associations of height, leg length, sitting height and menarcheal age with hormone receptor-defined malignancies. Within the European Prospective Investigation into Cancer and Nutrition cohort, Cox proportional hazards models were used to describe the relationships of adult height, leg length and sitting height and age at menarche with risk of estrogen and progesterone receptor negative (ER-PR-) (n = 990) and ER+PR+ (n = 3,524) breast tumors. Height as a single risk factor was compared to a model combining leg length and sitting height. The possible interactions of height, leg length and sitting height with menarche were also analyzed. Risk of both ER-PR- and ER+PR+ malignancies was positively associated with standing height, leg length and sitting height and inversely associated with increasing age at menarche. For ER+PR+ disease, sitting height (hazard ratios: 1.14[95% confidence interval: 1.08-1.20]) had a stronger risk association than leg length (1.05[1.00-1.11]). In comparison, for ER-PR- disease, no distinct differences were observed between leg length and sitting height. Women who were tall and had an early menarche (≤13 years) showed an almost twofold increase in risk of ER+PR+ tumors but no such increase in risk was observed for ER-PR- disease. Indicators of exposures during rapid growth periods were associated with risks of both HR-defined breast cancers. Exposures during childhood promoting faster development may establish risk associations for both HR-positive and -negative malignancies. The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women. What's new? Adult height and early age at menarche are established risk factors for breast cancer. In this study, the authors examined these factors in relation to the hormone-receptor status of breast tumors, with height divided into leg length vs. sitting height. They found that women who were tall and had an early menarche (≤13 years) had almost double the risk of developing estrogen/progesterone-positive (ER+PR+) tumors. Leg length and early menarche were also associated with increased risk for receptor-negative (ER-PR-) tumors. In addition, the data suggest possible hormonal links that could be specific for postmenopausal women.

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