Height of children off therapy after acute lymphoblastic leukemia

Maria Grazia Zurlo, Elisabetta Senesi, Benedetto Terracini, Donato Balducci, Pierfranco Biddau, Paolo D'Angelo, Domenico Rosati, Stefano Gandus, Enrico Madon, Antonia Mancini, Luigi Nespoli, Gabriella Piacentini, Sultana Razon Veronesi, Paolo Tamaro

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 290 children off therapy after acute lymphoblastic leukemia, in continuous complete remission for at least 2 years, were evaluated for height at the onset of the disease and at the most recent clinical visit (median time after suspension of treatment 4 years 4 months, range 2 years-11 years 3 months). All patients had been treated with multidrug schedules; intrathecal drugs had been given to 84% of the patients for prevention of CNS involvement, associated with radiotherapy. The height percentiles at the most recent examination were shifted downward significantly compared with the expected pattern (p <0.001). The effect on stature was much more marked in girls, with a reduction of height percentiles at most recent examination from expected and from diagnosis; in males there was a reduction from diagnosis to latest follow-up, but the values were within the limits of normal. The short stature was mostly observed in pubertal girls and in patients who had undergone radiotherapy.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalPediatric Hematology and Oncology
Volume5
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Acute leukemia
  • Childhood
  • Height

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

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