Heightened thrombin formation but normal plasma levels of activated factor VII in patients with acute coronary syndromes

P. A. Merlini, D. Ardissino, L. Oltrona, M. Broccolino, R. Coppola, P. M. Mannucci

Research output: Contribution to journalArticlepeer-review

Abstract

Plaque rupture with the exposure of a tissue factor-rich procoagulant surface is considered the common pathogenetic mechanism of unstable angina and myocardial infarction. Activated factor VII, the key enzyme for initiating blood coagulation under resting conditions, is increased in pathological situations associated with tissue factor exposure. We measured the plasma levels of activated factor VII and studied their relation with signs of coagulation enzyme activity in patients with acute coronary syndromes. The plasma levels of activated factor VII, prothrombin fragment 1 + 2, and fibrinopeptide A were measured on admission in consecutive patients presenting with acute myocardial infarction (n = 28), unstable angina (n = 32), and stable angina (n = 17) and in age- and sex-matched healthy individuals (n = 33). Plasma determinations of the same markers were also repeated at 15 days and 3 and 6 months. On admission, the patients with unstable angina or myocardial infarction had significantly higher plasma levels of prothrombin fragment 1 + 2 (P

Original languageEnglish
Pages (from-to)1675-1679
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume15
Issue number10
Publication statusPublished - 1995

Keywords

  • activated factor VII
  • acute coronary syndromes
  • prothrombin fragment 1 + 2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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