Helicobacter pylori-associated large gastric ulcer during treatment for childhood leukemia

Francesca Fioredda, Riccardo Haupt, Elio Castagnola, Arrigo Barabino, Concetta Micalizzi, Giorgio Dini, Carlo Dufour

Research output: Contribution to journalArticlepeer-review


During treatment of acute lymphoblastic leukemia, serious gastrointestinal complications rarely occur in children. Helicobacter pylori is not known as a pathogen causing peptic ulcer in children with leukemia who are receiving chemotherapy. We describe a 14-year-old girl with acute lymphoblastic leukemia in whom, during the most aggressive part of treatment, a large, life-threatening H. pylori-associated gastric ulcer developed. H. pylori infection played a role in the origin of the ulcer, as confirmed by the clinical resolution after its specific treatment. This case points to a possible role for H. pylori as a pathogen in children with leukemia who have either evident or occult gastrointestinal bleeding.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number9
Publication statusPublished - Dec 2002


  • Childhood leukemia
  • Corticosteroids
  • Helicobacter pylori
  • Toxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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