Abstract
Aim. Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacterpylori (H- pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40%, this antibiotic would be preferable as first approach. The aim of this randomized study was to assess the efficacy of a metronidazole - based versus a tinidazole-based treatment, in naive patients with H pylori infection. Methods. Diagnosis and eradication of H pylori infection were assessed by 13C-urea breath test, and by histology when an endoscopic examination was necessary. A total of 171 patients was treated: 91 (47 males, mean age 50±3 years)with metronidazole 250 mg q.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (MAO), and 80 (36 males, mean age 52±3.8 years) with tinidazole 500 mg b.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (TAO) regimen for 7,10 or 14 days. Results. Three patients suspended MAO treatment due to side effects. H. pylori eradication was obtained as follow indicated. After 7 days, in 23/30 (76.6%) patients in MAO versus 20/27 (74.0%) in TAO regimen. After 10 days, in 20/26 (76.9%) patients in MAO versus 20/26 (76.9%) in TAO regimen. After 14 days, in 25/32 subjects (78.1%) in MAO versus 21/27 (77.7%) in TAO treatment. The differences among durations or between metronidazole-versus tinldazole-based triple therapy were not statistically different. Conclusion. Treatment with metronidazole is as effective as that with tinidazole in terms of efficacy. Moreover, duration did not influence efficacy of treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 355-358 |
| Number of pages | 4 |
| Journal | Minerva Gastroenterologica e Dietologica |
| Volume | 54 |
| Issue number | 4 |
| Publication status | Published - Dec 2008 |
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Keywords
- Helicobacter pylori
- Metronidazole
- Tinidazole
ASJC Scopus subject areas
- Gastroenterology
- Internal Medicine
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
Cite this
Helicobacter pylori eradication : Metronidazole or tinidazole? Data from Turin, Italy. / Berrutti, M.; Pellicano, R.; Astegiano, M.; Smedile, A.; Saracco, G.; Morgando, A.; De Angelis, C.; Repici, A.; Fagoonee, S.; Leone, N.; Rizzetto, M.
In: Minerva Gastroenterologica e Dietologica, Vol. 54, No. 4, 12.2008, p. 355-358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Helicobacter pylori eradication
T2 - Metronidazole or tinidazole? Data from Turin, Italy
AU - Berrutti, M.
AU - Pellicano, R.
AU - Astegiano, M.
AU - Smedile, A.
AU - Saracco, G.
AU - Morgando, A.
AU - De Angelis, C.
AU - Repici, A.
AU - Fagoonee, S.
AU - Leone, N.
AU - Rizzetto, M.
PY - 2008/12
Y1 - 2008/12
N2 - Aim. Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacterpylori (H- pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40%, this antibiotic would be preferable as first approach. The aim of this randomized study was to assess the efficacy of a metronidazole - based versus a tinidazole-based treatment, in naive patients with H pylori infection. Methods. Diagnosis and eradication of H pylori infection were assessed by 13C-urea breath test, and by histology when an endoscopic examination was necessary. A total of 171 patients was treated: 91 (47 males, mean age 50±3 years)with metronidazole 250 mg q.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (MAO), and 80 (36 males, mean age 52±3.8 years) with tinidazole 500 mg b.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (TAO) regimen for 7,10 or 14 days. Results. Three patients suspended MAO treatment due to side effects. H. pylori eradication was obtained as follow indicated. After 7 days, in 23/30 (76.6%) patients in MAO versus 20/27 (74.0%) in TAO regimen. After 10 days, in 20/26 (76.9%) patients in MAO versus 20/26 (76.9%) in TAO regimen. After 14 days, in 25/32 subjects (78.1%) in MAO versus 21/27 (77.7%) in TAO treatment. The differences among durations or between metronidazole-versus tinldazole-based triple therapy were not statistically different. Conclusion. Treatment with metronidazole is as effective as that with tinidazole in terms of efficacy. Moreover, duration did not influence efficacy of treatment.
AB - Aim. Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacterpylori (H- pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40%, this antibiotic would be preferable as first approach. The aim of this randomized study was to assess the efficacy of a metronidazole - based versus a tinidazole-based treatment, in naive patients with H pylori infection. Methods. Diagnosis and eradication of H pylori infection were assessed by 13C-urea breath test, and by histology when an endoscopic examination was necessary. A total of 171 patients was treated: 91 (47 males, mean age 50±3 years)with metronidazole 250 mg q.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (MAO), and 80 (36 males, mean age 52±3.8 years) with tinidazole 500 mg b.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (TAO) regimen for 7,10 or 14 days. Results. Three patients suspended MAO treatment due to side effects. H. pylori eradication was obtained as follow indicated. After 7 days, in 23/30 (76.6%) patients in MAO versus 20/27 (74.0%) in TAO regimen. After 10 days, in 20/26 (76.9%) patients in MAO versus 20/26 (76.9%) in TAO regimen. After 14 days, in 25/32 subjects (78.1%) in MAO versus 21/27 (77.7%) in TAO treatment. The differences among durations or between metronidazole-versus tinldazole-based triple therapy were not statistically different. Conclusion. Treatment with metronidazole is as effective as that with tinidazole in terms of efficacy. Moreover, duration did not influence efficacy of treatment.
KW - Helicobacter pylori
KW - Metronidazole
KW - Tinidazole
UR - http://www.scopus.com/inward/record.url?scp=59749084745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59749084745&partnerID=8YFLogxK
M3 - Article
C2 - 19047976
AN - SCOPUS:59749084745
VL - 54
SP - 355
EP - 358
JO - Minerva Gastroenterologica
JF - Minerva Gastroenterologica
SN - 0026-4776
IS - 4
ER -