Helicobacter pylori eradication

Metronidazole or tinidazole? Data from Turin, Italy

M. Berrutti, R. Pellicano, M. Astegiano, A. Smedile, G. Saracco, A. Morgando, C. De Angelis, A. Repici, S. Fagoonee, N. Leone, M. Rizzetto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim. Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacterpylori (H- pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40%, this antibiotic would be preferable as first approach. The aim of this randomized study was to assess the efficacy of a metronidazole - based versus a tinidazole-based treatment, in naive patients with H pylori infection. Methods. Diagnosis and eradication of H pylori infection were assessed by 13C-urea breath test, and by histology when an endoscopic examination was necessary. A total of 171 patients was treated: 91 (47 males, mean age 50±3 years)with metronidazole 250 mg q.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (MAO), and 80 (36 males, mean age 52±3.8 years) with tinidazole 500 mg b.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (TAO) regimen for 7,10 or 14 days. Results. Three patients suspended MAO treatment due to side effects. H. pylori eradication was obtained as follow indicated. After 7 days, in 23/30 (76.6%) patients in MAO versus 20/27 (74.0%) in TAO regimen. After 10 days, in 20/26 (76.9%) patients in MAO versus 20/26 (76.9%) in TAO regimen. After 14 days, in 25/32 subjects (78.1%) in MAO versus 21/27 (77.7%) in TAO treatment. The differences among durations or between metronidazole-versus tinldazole-based triple therapy were not statistically different. Conclusion. Treatment with metronidazole is as effective as that with tinidazole in terms of efficacy. Moreover, duration did not influence efficacy of treatment.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalMinerva Gastroenterologica e Dietologica
Volume54
Issue number4
Publication statusPublished - Dec 2008

Fingerprint

Tinidazole
Metronidazole
Troleandomycin
Helicobacter pylori
Monoamine Oxidase
Italy
Proton Pump Inhibitors
Pylorus
Amoxicillin
Therapeutics
Infection
Anti-Bacterial Agents
Breath Tests
Urea
Histology
Population

Keywords

  • Helicobacter pylori
  • Metronidazole
  • Tinidazole

ASJC Scopus subject areas

  • Gastroenterology
  • Internal Medicine
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Berrutti, M., Pellicano, R., Astegiano, M., Smedile, A., Saracco, G., Morgando, A., ... Rizzetto, M. (2008). Helicobacter pylori eradication: Metronidazole or tinidazole? Data from Turin, Italy. Minerva Gastroenterologica e Dietologica, 54(4), 355-358.

Helicobacter pylori eradication : Metronidazole or tinidazole? Data from Turin, Italy. / Berrutti, M.; Pellicano, R.; Astegiano, M.; Smedile, A.; Saracco, G.; Morgando, A.; De Angelis, C.; Repici, A.; Fagoonee, S.; Leone, N.; Rizzetto, M.

In: Minerva Gastroenterologica e Dietologica, Vol. 54, No. 4, 12.2008, p. 355-358.

Research output: Contribution to journalArticle

Berrutti, M, Pellicano, R, Astegiano, M, Smedile, A, Saracco, G, Morgando, A, De Angelis, C, Repici, A, Fagoonee, S, Leone, N & Rizzetto, M 2008, 'Helicobacter pylori eradication: Metronidazole or tinidazole? Data from Turin, Italy', Minerva Gastroenterologica e Dietologica, vol. 54, no. 4, pp. 355-358.
Berrutti M, Pellicano R, Astegiano M, Smedile A, Saracco G, Morgando A et al. Helicobacter pylori eradication: Metronidazole or tinidazole? Data from Turin, Italy. Minerva Gastroenterologica e Dietologica. 2008 Dec;54(4):355-358.
Berrutti, M. ; Pellicano, R. ; Astegiano, M. ; Smedile, A. ; Saracco, G. ; Morgando, A. ; De Angelis, C. ; Repici, A. ; Fagoonee, S. ; Leone, N. ; Rizzetto, M. / Helicobacter pylori eradication : Metronidazole or tinidazole? Data from Turin, Italy. In: Minerva Gastroenterologica e Dietologica. 2008 ; Vol. 54, No. 4. pp. 355-358.
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abstract = "Aim. Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacterpylori (H- pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40{\%}, this antibiotic would be preferable as first approach. The aim of this randomized study was to assess the efficacy of a metronidazole - based versus a tinidazole-based treatment, in naive patients with H pylori infection. Methods. Diagnosis and eradication of H pylori infection were assessed by 13C-urea breath test, and by histology when an endoscopic examination was necessary. A total of 171 patients was treated: 91 (47 males, mean age 50±3 years)with metronidazole 250 mg q.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (MAO), and 80 (36 males, mean age 52±3.8 years) with tinidazole 500 mg b.i.d., amoxicilline 1 gr b.i.d. and PPI standard dose (TAO) regimen for 7,10 or 14 days. Results. Three patients suspended MAO treatment due to side effects. H. pylori eradication was obtained as follow indicated. After 7 days, in 23/30 (76.6{\%}) patients in MAO versus 20/27 (74.0{\%}) in TAO regimen. After 10 days, in 20/26 (76.9{\%}) patients in MAO versus 20/26 (76.9{\%}) in TAO regimen. After 14 days, in 25/32 subjects (78.1{\%}) in MAO versus 21/27 (77.7{\%}) in TAO treatment. The differences among durations or between metronidazole-versus tinldazole-based triple therapy were not statistically different. Conclusion. Treatment with metronidazole is as effective as that with tinidazole in terms of efficacy. Moreover, duration did not influence efficacy of treatment.",
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