Helicobacter pylori infection and respiratory diseases: Actual data and directions for future studies

A. Adriani, A. Repici, I. Hickman, R. Pellicano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) has been conclusively related to several gastroduodenal diseases. The possible role of the bacterium in the development of extragastric manifestations has been investigated in the past few years. To identify all publications on the association between H. pylori and respiratory diseases, a MEDLINE search of all studies published in English from 1965 to 2013 was conducted. All data are based on case-control studies. Controversial findings of H. pylori seroprevalence have been obtained in patients with bronchial asthma, lung cancer, pulmonary tuberculosis, sarcoidosis, cystic fibrosis, chronic bronchitis and bronchiectasis. At present, on epidemiological bases, there is no definite evidence of a causal relationship between H. pylori infection and respiratory diseases. There is a low consideration of confounding factors as poorer socioeconomic status and tobacco use. The activation of proinflammatory cytokines by H. pylori might be a possible pathogenetic mechanism. However, there are no convincing data about the influence of H. pylori on the inflammatory changes of the bronchoepithelium so far. Further studies are needed on the impact of H. pylori eradication, on the prevention, development and natural history of these disorders.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMinerva Medica
Volume105
Issue number1
Publication statusPublished - 2014

Fingerprint

Helicobacter Infections
Helicobacter pylori
Pulmonary Sarcoidosis
Bronchiectasis
Chronic Bronchitis
Seroepidemiologic Studies
Tobacco Use
Direction compound
Natural History
Pulmonary Tuberculosis
Cystic Fibrosis
Social Class
MEDLINE
Publications
Case-Control Studies
Lung Neoplasms
Asthma
Cytokines
Bacteria

Keywords

  • Asthma
  • Bronchitis
  • Helicobacter pylori
  • Respiratory disorders

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Helicobacter pylori infection and respiratory diseases : Actual data and directions for future studies. / Adriani, A.; Repici, A.; Hickman, I.; Pellicano, R.

In: Minerva Medica, Vol. 105, No. 1, 2014, p. 1-8.

Research output: Contribution to journalArticle

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