Helicobacter pylori infection and the risk of myocardial infarction: Role of fibrinogen and its genetic control

Francesco Zito, Augusto Di Castelnuovo, Andria D'Orazio, Riccardo Negrini, Domenico De Lucia, Maria Benedetta Donati, Licia Lacoviello

Research output: Contribution to journalArticlepeer-review

Abstract

The contribution of Helicobacter pylori (HP) infection to the risk of myocardial infarction was evaluated. The role of fibrinogen and its generic control as a possible mechanism by which HP may influence myocardial infarction risk was explored in this context. A case-control study was performed in 101 patients with myocardial infarction and in 101 controls. HP infection was associated with an increased risk of myocardial infarction independently for confounding variables (OR 4.1, CI95: 1.8-9.4). HP infection was significantly associated with higher levels of fibrinogen, both in cases and in controls. Furthermore there was an additive effect of HP infection and B2 allele of BcII fibrinogen polymorphism in increasing fibrinogen levels. HP infection showed a stronger effect on the risk of myocardial infarction in B2 allele carriers (OR 7.6, CI95: 1.8-31.6) as compared to subjects carrying the B1B1 genotype (OR 3.3, CI95: 1.2-9.2). We showed that a previous HP infection is a risk factor for myocardial infarction. An increase in fibrinogen levels is a possible mechanism by which HP may act. Concomitant conditions, like a genetic predisposition in increasing fibrinogen levels, seem to further increase the effect of HP on myocardial infarction risk.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalThrombosis and Haemostasis
Volume82
Issue number1
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Hematology

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