Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa

Abderrahim Oussalah, Cyril Besseau, Céline Chery, Elise Jeannesson, Rosa Maria Guéant-Rodriguez, Guido Anello, Paolo Bosco, Maurizzio Elia, Antonino Romano, Jean Pierre Bronowicki, Philippe Gerard, Justine Paoli, Patrice Hodonou Avogbe, Nicodème Chabi, Ambaliou Sanni, Emile Amouzou, Laurent Peyrin-Biroulet, Jean Louis Guéant

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Abstract

Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P <0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa.

Original languageEnglish
Pages (from-to)514-521
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume95
Issue number2
DOIs
Publication statusPublished - Feb 1 2012

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Western Africa
Vitamin B 12
Helicobacter pylori
Serology
Genotype
Methylmalonic Acid
Helicobacter Infections
Homocysteine
galactoside 2-alpha-L-fucosyltransferase
Folic Acid
Population
Real-Time Polymerase Chain Reaction
Multivariate Analysis
Enzyme-Linked Immunosorbent Assay
Genes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa. / Oussalah, Abderrahim; Besseau, Cyril; Chery, Céline; Jeannesson, Elise; Guéant-Rodriguez, Rosa Maria; Anello, Guido; Bosco, Paolo; Elia, Maurizzio; Romano, Antonino; Bronowicki, Jean Pierre; Gerard, Philippe; Paoli, Justine; Avogbe, Patrice Hodonou; Chabi, Nicodème; Sanni, Ambaliou; Amouzou, Emile; Peyrin-Biroulet, Laurent; Guéant, Jean Louis.

In: American Journal of Clinical Nutrition, Vol. 95, No. 2, 01.02.2012, p. 514-521.

Research output: Contribution to journalArticle

Oussalah, A, Besseau, C, Chery, C, Jeannesson, E, Guéant-Rodriguez, RM, Anello, G, Bosco, P, Elia, M, Romano, A, Bronowicki, JP, Gerard, P, Paoli, J, Avogbe, PH, Chabi, N, Sanni, A, Amouzou, E, Peyrin-Biroulet, L & Guéant, JL 2012, 'Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa', American Journal of Clinical Nutrition, vol. 95, no. 2, pp. 514-521. https://doi.org/10.3945/ajcn.111.016410
Oussalah, Abderrahim ; Besseau, Cyril ; Chery, Céline ; Jeannesson, Elise ; Guéant-Rodriguez, Rosa Maria ; Anello, Guido ; Bosco, Paolo ; Elia, Maurizzio ; Romano, Antonino ; Bronowicki, Jean Pierre ; Gerard, Philippe ; Paoli, Justine ; Avogbe, Patrice Hodonou ; Chabi, Nicodème ; Sanni, Ambaliou ; Amouzou, Emile ; Peyrin-Biroulet, Laurent ; Guéant, Jean Louis. / Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa. In: American Journal of Clinical Nutrition. 2012 ; Vol. 95, No. 2. pp. 514-521.
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abstract = "Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P <0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa.",
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T1 - Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa

AU - Oussalah, Abderrahim

AU - Besseau, Cyril

AU - Chery, Céline

AU - Jeannesson, Elise

AU - Guéant-Rodriguez, Rosa Maria

AU - Anello, Guido

AU - Bosco, Paolo

AU - Elia, Maurizzio

AU - Romano, Antonino

AU - Bronowicki, Jean Pierre

AU - Gerard, Philippe

AU - Paoli, Justine

AU - Avogbe, Patrice Hodonou

AU - Chabi, Nicodème

AU - Sanni, Ambaliou

AU - Amouzou, Emile

AU - Peyrin-Biroulet, Laurent

AU - Guéant, Jean Louis

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P <0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa.

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