Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G→A) and vitamin B-12 in Europe and West Africa

Abderrahim Oussalah, Cyril Besseau, Céline Chery, Elise Jeannesson, Rosa Maria Guéant-Rodriguez, Guido Anello, Paolo Bosco, Maurizzio Elia, Antonino Romano, Jean Pierre Bronowicki, Philippe Gerard, Justine Paoli, Patrice Hodonou Avogbe, Nicodème Chabi, Ambaliou Sanni, Emile Amouzou, Laurent Peyrin-Biroulet, Jean Louis Guéant

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Genomewide association studies have shown a relation between plasma vitamin B-12 concentration and the 461G→A polymorphism of fucosyltransferase 2 (FUT2), a gene associated with susceptibility to Helicobacter pylori infection. Objective: We evaluated in 2 populations the association of FUT2 461 G→A polymorphism with vitamin B-12 and related metabolic markers and investigated whether the influence of FUT2 on H. pylori serology is part of the mechanisms that underlie these associations. Design: The study included 1282 ambulatory subjects from Europe and West Africa. Blood concentrations of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured. Genotyping was performed by real-time polymerase chain reaction. H. pylori serology testing was performed by using ELISA. Results: In univariate analysis, FUT2 461 A/A genotype was associated with higher plasma vitamin B-12 concentration in the total population (P = 0.0007) as well as in Europe (P = 0.0009) and in West Africa (P = 0.0015). Positivity for H. pylori serology was higher in West Africa (P <0.0001) and was not associated with low plasma vitamin B-12. The prevalence of H. pylori-positive patients did not differ among FUT2 461 G→A genotypes (P = 0.2068). In multivariate analysis, FUT2 461 G→A genotype (P = 0.0008), but not positive H. pylori serology, was an independent predictor of plasma vitamin B-12 concentration. Conclusion: This study confirms the influence of FUT2 461 G→A polymorphism on plasma vitamin B-12 concentration and showed no influence of H. pylori serologic status on this association in ambulatory subjects from Europe and West Africa.

Original languageEnglish
Pages (from-to)514-521
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume95
Issue number2
DOIs
Publication statusPublished - Feb 1 2012

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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