Helper T-cell responses in children infected with human immunodeficiency virus type 1

Emmanuel Roilides, Mario Clerici, Louis DePalma, Marc Rubin, Philip A. Pizzo, Gene M. Shearer

Research output: Contribution to journalArticlepeer-review

Abstract

Helper T-cell function was evaluated in 34 children infected with human immunodeficlency virus type 1, by assessing interleukin-2 production after stimulation of peripheral blood mononuclear cells with recall antigens (influenza virus, tetanus toxoid), allogeneic HLA, and phytohemagglutinin. In addition, helper T-cell function was correlated retrospectively with the incidence of opportunistic and bacterial infections. Four patterns of helper T-cell function were observed: (1) 7 (21%) of the 34 children responded to all stimuli, (2) 7 (21%) of them responded to alloantigens and phytohemagglutinin but not to recall antigens, (3) 7 (21%) responded to phytohemagglutinin but not to recall antigens or alloantigens, and (4) 13 (37%) did not respond to any of these stimuli. There were no significant differences related to different routes of acquisition among patients. Patients with functional helper T-cell defects had a history of more opportunistic (p=0.03) and bacterial (p

Original languageEnglish
Pages (from-to)724-730
Number of pages7
JournalJournal of Pediatrics
Volume118
Issue number5
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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