Hema e-Chart Registry of invasive fungal infections in haematological patients: Improved outcome in recent years in mould infections

A. M. Nosari, M. Caira, M. L. Pioltelli, R. Fanci, A. Bonini, C. Cattaneo, C. Castagnola, S. F. Capalbo, P. De Fabritiis, V. Mettivier, M. Morselli, D. Pastore, F. Aversa, G. Rossi, L. Pagano

Research output: Contribution to journalArticle

Abstract

Clin Microbiol Infect The electronic surveillance system Hema e-Chart allowed us to prospectively collect data and to perform an analysis of invasive fungal infections (IFI) diagnosed in febrile patients as well as the procedures allowing their diagnosis and outcome according to the treatment given. Every patient admitted to 26 Italian Haematology Units with a new diagnosis of haematological malignancy and who was a candidate for chemotherapy was consecutively registered between March 2007 and March 2009. In all, 147 haematological patients with mycoses were identified. Yeasts were found in 23 infections; moulds were diagnosed in 17 proven, 35 probable and 72 possible mycoses. Galactomannan (GM) antigen was the most important test to diagnose probable mould infection; it was positive (cut-off >0.5) in 27 (77%) probable and in nine (53%) proven mould infections. Among patients with probable/proven mould infection who received no prophylaxis or non-mould-active prophylaxis with fluconazole, more patients (n=26, 78.8%) had GM antigen positivity compared with patients (n=10, 52.6%) given prophylaxis with mould-active drugs (p

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalClinical Microbiology and Infection
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Attributable mortality
  • Galactomannan antigen
  • Haematological malignancies
  • Mould infections
  • Yeast infections

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Nosari, A. M., Caira, M., Pioltelli, M. L., Fanci, R., Bonini, A., Cattaneo, C., Castagnola, C., Capalbo, S. F., De Fabritiis, P., Mettivier, V., Morselli, M., Pastore, D., Aversa, F., Rossi, G., & Pagano, L. (2013). Hema e-Chart Registry of invasive fungal infections in haematological patients: Improved outcome in recent years in mould infections. Clinical Microbiology and Infection, 19(8), 757-762. https://doi.org/10.1111/1469-0691.12014