Abstract
Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 6cells/mm 3 vs. 4.48×10 6cells/mm 3, P
| Original language | English |
|---|---|
| Pages (from-to) | 551-556 |
| Number of pages | 6 |
| Journal | Journal of Medical Virology |
| Volume | 83 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
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Keywords
- Antiretroviral therapy
- HIV
- Pediatrics anemia
- Zidovudine
ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine. / Baroncelli, Silvia; Pinnetti, Carmela; Genovese, Orazio; Tamburrini, Enrica; Floridia, Marco.
In: Journal of Medical Virology, Vol. 83, No. 3, 03.2011, p. 551-556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine
AU - Baroncelli, Silvia
AU - Pinnetti, Carmela
AU - Genovese, Orazio
AU - Tamburrini, Enrica
AU - Floridia, Marco
PY - 2011/3
Y1 - 2011/3
N2 - Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 6cells/mm 3 vs. 4.48×10 6cells/mm 3, P
AB - Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 6cells/mm 3 vs. 4.48×10 6cells/mm 3, P
KW - Antiretroviral therapy
KW - HIV
KW - Pediatrics anemia
KW - Zidovudine
UR - http://www.scopus.com/inward/record.url?scp=78851472222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78851472222&partnerID=8YFLogxK
U2 - 10.1002/jmv.21986
DO - 10.1002/jmv.21986
M3 - Article
C2 - 21264878
AN - SCOPUS:78851472222
VL - 83
SP - 551
EP - 556
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 3
ER -