Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine

Silvia Baroncelli, Carmela Pinnetti, Orazio Genovese, Enrica Tamburrini, Marco Floridia

Research output: Contribution to journalArticlepeer-review

Abstract

Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 6cells/mm 3 vs. 4.48×10 6cells/mm 3, P

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalJournal of Medical Virology
Volume83
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Antiretroviral therapy
  • HIV
  • Pediatrics anemia
  • Zidovudine

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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