Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine

Silvia Baroncelli; Carmela Pinnetti; Orazio Genovese; Enrica Tamburrini; Marco Floridia

doi:10.1002/jmv.21986

Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine

Silvia Baroncelli, Carmela Pinnetti, Orazio Genovese, Enrica Tamburrini, Marco Floridia

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 ⁶cells/mm ³ vs. 4.48×10 ⁶cells/mm ³, P

Original language	English
Pages (from-to)	551-556
Number of pages	6
Journal	Journal of Medical Virology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1002/jmv.21986
Publication status	Published - Mar 2011

Keywords

Antiretroviral therapy
HIV
Pediatrics anemia
Zidovudine

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1002/jmv.21986

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abstract = "Postnatal prophylaxis with oral zidovudine (ZDV) is associated with hematological effects. However, it is still unknown whether selection of non-ZDV-based regimens in pregnancy may reduce hematological toxicity associated with postnatal ZDV prophylaxis. The aim of this study was to define the hematological effects of ZDV prophylaxis in newborns with and without prenatal exposure to ZDV. Sixty-five newborns from mothers infected with HIV who, during pregnancy, received HAART regimens with (n:44) and without (n:21) ZDV were evaluated. Virological and hematological data were compared at birth and at 4 weeks and 6 months of life. Newborns with prenatal ZDV exposure had significantly worse hematological values at birth, with lower levels of hemoglobin (14.3g/dl vs. 16.2g/dl, P=0.001), red blood cell count (3.45×10 6cells/mm 3 vs. 4.48×10 6cells/mm 3, P",

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author = "Silvia Baroncelli and Carmela Pinnetti and Orazio Genovese and Enrica Tamburrini and Marco Floridia",

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AU - Genovese, Orazio

AU - Tamburrini, Enrica

AU - Floridia, Marco

PY - 2011/3

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