Abstract
To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the "Rete Ematologica Lombarda". According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.
| Original language | English |
|---|---|
| Pages (from-to) | 1233-1240 |
| Number of pages | 8 |
| Journal | Leukemia Research |
| Volume | 37 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2013 |
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Keywords
- Hematological improvement
- Iron-chelation therapy
- Myelodysplastic syndromes
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Hematological improvement during iron-chelation therapy in myelodysplastic syndromes : The experience of the "Rete Ematologica Lombarda". / Molteni, Alfredo; Riva, Marta; Pellizzari, Annamaria; Borin, Lorenza; Freyre, Alessandra; Greco, Rosa; Ubezio, Marta; Bernardi, Massimo; Fariciotti, Alessio; Nador, Guido; Nichelatti, Michele; Ravano, Emanuele; Morra, Enrica.
In: Leukemia Research, Vol. 37, No. 10, 10.2013, p. 1233-1240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hematological improvement during iron-chelation therapy in myelodysplastic syndromes
T2 - The experience of the "Rete Ematologica Lombarda"
AU - Molteni, Alfredo
AU - Riva, Marta
AU - Pellizzari, Annamaria
AU - Borin, Lorenza
AU - Freyre, Alessandra
AU - Greco, Rosa
AU - Ubezio, Marta
AU - Bernardi, Massimo
AU - Fariciotti, Alessio
AU - Nador, Guido
AU - Nichelatti, Michele
AU - Ravano, Emanuele
AU - Morra, Enrica
PY - 2013/10
Y1 - 2013/10
N2 - To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the "Rete Ematologica Lombarda". According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.
AB - To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the "Rete Ematologica Lombarda". According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.
KW - Hematological improvement
KW - Iron-chelation therapy
KW - Myelodysplastic syndromes
UR - http://www.scopus.com/inward/record.url?scp=84883554593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883554593&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2013.07.006
DO - 10.1016/j.leukres.2013.07.006
M3 - Article
C2 - 23906627
AN - SCOPUS:84883554593
VL - 37
SP - 1233
EP - 1240
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 10
ER -