Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the "Rete Ematologica Lombarda"

Alfredo Molteni; Marta Riva; Annamaria Pellizzari; Lorenza Borin; Alessandra Freyre; Rosa Greco; Marta Ubezio; Massimo Bernardi; Alessio Fariciotti; Guido Nador; Michele Nichelatti; Emanuele Ravano; Enrica Morra

doi:10.1016/j.leukres.2013.07.006

Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the "Rete Ematologica Lombarda"

Alfredo Molteni, Marta Riva, Annamaria Pellizzari, Lorenza Borin, Alessandra Freyre, Rosa Greco, Marta Ubezio, Massimo Bernardi, Alessio Fariciotti, Guido Nador, Michele Nichelatti, Emanuele Ravano, Enrica Morra

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the "Rete Ematologica Lombarda". According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.

Original language	English
Pages (from-to)	1233-1240
Number of pages	8
Journal	Leukemia Research
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.leukres.2013.07.006
Publication status	Published - Oct 2013

Keywords

Hematological improvement
Iron-chelation therapy
Myelodysplastic syndromes

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2013.07.006

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Molteni, A., Riva, M., Pellizzari, A., Borin, L., Freyre, A., Greco, R., Ubezio, M., Bernardi, M., Fariciotti, A., Nador, G., Nichelatti, M., Ravano, E., & Morra, E. (2013). Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the "Rete Ematologica Lombarda". Leukemia Research, 37(10), 1233-1240. https://doi.org/10.1016/j.leukres.2013.07.006

Hematological improvement during iron-chelation therapy in myelodysplastic syndromes : The experience of the "Rete Ematologica Lombarda". / Molteni, Alfredo; Riva, Marta; Pellizzari, Annamaria; Borin, Lorenza; Freyre, Alessandra; Greco, Rosa; Ubezio, Marta; Bernardi, Massimo; Fariciotti, Alessio; Nador, Guido; Nichelatti, Michele; Ravano, Emanuele; Morra, Enrica.

In: Leukemia Research, Vol. 37, No. 10, 10.2013, p. 1233-1240.

Research output: Contribution to journal › Article › peer-review

Molteni, A, Riva, M, Pellizzari, A, Borin, L, Freyre, A, Greco, R, Ubezio, M, Bernardi, M, Fariciotti, A, Nador, G, Nichelatti, M, Ravano, E & Morra, E 2013, 'Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the "Rete Ematologica Lombarda"', Leukemia Research, vol. 37, no. 10, pp. 1233-1240. https://doi.org/10.1016/j.leukres.2013.07.006

Molteni, Alfredo ; Riva, Marta ; Pellizzari, Annamaria ; Borin, Lorenza ; Freyre, Alessandra ; Greco, Rosa ; Ubezio, Marta ; Bernardi, Massimo ; Fariciotti, Alessio ; Nador, Guido ; Nichelatti, Michele ; Ravano, Emanuele ; Morra, Enrica. / Hematological improvement during iron-chelation therapy in myelodysplastic syndromes : The experience of the "Rete Ematologica Lombarda". In: Leukemia Research. 2013 ; Vol. 37, No. 10. pp. 1233-1240.

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abstract = "To analyze the unpredicted event of hematological improvement (HI) during iron-chelation therapy (ICT), we reviewed a series of 53 myelodysplastic patients with transfusion dependency in a retrospective study involving 8 centers afferent to the {"}Rete Ematologica Lombarda{"}. According to the IWG response criteria published in the year 2000, we observed erythroid responses in 19 patients (35.1%), 5 major (9.2%) and 14 minor (25.9%). In the assessable patients, platelet response was 8/13 (61%) and neutrophil response was 13/17 (76.4%). Only in patients with erythroid improvement, multilineage responses were observed. Apparently, patients with greater erythropoiesis dysfunction may take more advantage.",

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AU - Bernardi, Massimo

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Hematological improvement during iron-chelation therapy in myelodysplastic syndromes: The experience of the "Rete Ematologica Lombarda"

Abstract

Keywords

ASJC Scopus subject areas

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