Hematological recovery after autologous bone marrow transplantation for high-grade non Hodgkin's lymphomas: A single center experience

M. C. Miggiano, F. Gherlinzoni, G. Visani, A. Belardinelli, P. Ricci, G. Rosti, P. Mazza, M. R. Motta, S. Rizzi, R. M. Lemoli, P. L. Zinzani, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Both rhGM-CSF and rhG-CSF can accelerate hematological recovery after high-dose therapy and autologous bone marrow transplantation in patients with high grade non Hodgkin's lymphoma and reduce transplant-related morbidity after ABMT. Methods. The clinical course of 23 non randomized patients was analyzed and compared with a historical control group of 10 patients. Ten patients received GM-CSF at a dose of 10 μg/kg in a 6-h IV infusion, and 13 received G-CSF at a dose of 5 μg/kg subcutaneously. Control patients received no GFs. Results. Mean granulocytic recovery to 0.5 x 109/L was obtained 13.1 ± 3.2 days after marrow reinfusion in the G-CSF arm vs 16 ± 2.7 in GM-CSF pts (p = 0.03) and vs 19.6 ± 7.6 in controls (p <0.01); this reduction led to a statistically significant shorter duration of fever and parenteral antibiotic therapy. Platelet recovery to 20 x 109/L was not significantly influenced by GFs. Conclusions. These results indicate that only G-CSF accelerates hematological recovery after high-dose chemotherapy and autologous bone marrow transplantation and induces a significant decrease in terms of infection morbidity and duration of hospital stay.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalHaematologica
Volume79
Issue number3
Publication statusPublished - 1994

Keywords

  • autologous bone marrow transplantation
  • growth factors
  • high-grade non Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

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