Hematopoietic cancer and angiogenesis

Domenico Ribatti, Claudio Scavelli, Aldo M. Roccaro, Enrico Crivellato, Beatrice Nico, Angelo Vacca

Research output: Contribution to journalArticlepeer-review


The growth of solid tumors is certainly angiogenesis dependent. However, the role of angiogenesis in the growth and survival of leukemias and other hematological malignancies has only been rendered evident since 1994 in a series of demonstrations showing that the progression of several forms is clearly related to their degree of angiogenesis. Here, we present an overview of the literature concerning the relationship between angiogenesis and disease progression in several hematological malignancies and the recent advances in antiangiogenesis in these diseases and we describe the most important active substances, preclinical and clinical data, and future pespectives.

Original languageEnglish
Pages (from-to)484-495
Number of pages12
JournalStem Cells and Development
Issue number5
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Hematology


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