Hematopoietic stem cell transplantation effects on spinal cord compression in Hurler

Giovanna Ferrara, Natalia Maximova, Floriana Zennaro, Massimo Gregori, Paolo Tamaro

Research output: Contribution to journalArticlepeer-review

Abstract

Hurler syndrome type 1 (MPS-1) is an autosomal recessive lysosomal disorder due to the deficiency of the enzyme alpha-L-iduronidase which is necessary for the degradation of dermatan and heparan sulfate. It is characterized by deposit of glycosaminoglycans in tissues, progressive multisystem dysfunction, and early death. HSCT for children with MPS-I is effective, resulting in increased life expectancy and improvement of clinical parameters. The spinal MRI performed on a female 10 yr old undergoing HSCT at the age of 18 months and receiving ERT revealed a considerable decrease in soft tissue around the tip of odontoid causing a significant reduction in spinal cord compression. In light of this result, we suppose that combined ERT and HSCT are successful in Hurler I disease.

Original languageEnglish
JournalPediatric Transplantation
Volume18
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • bone marrow transplantation
  • Hurler I
  • spinal cord compression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation
  • Medicine(all)

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