Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: A survey of the European Cooperative Group for Blood and Marrow Transplantation

M. A. Sanz, M. Labopin, N. C. Gorin, J. de la Rubia, W. Arcese, G. Meloni, A. Bacigalupo, P. Alessandrino, E. Carreras, A. Iriondo, N. Novitzky, P. Jacobs, G. Bandini, F. Lo-Coco, F. Frassoni, V. Rocha

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Abstract

We performed a survey of the European Cooperative Group for Blood and Marrow Transplantation to analyze the outcome of 625 acute promyelocytic leukemia (APL) patients transplanted with auto- or allogeneic-hematopoietic stem cell transplantation (autoHSCT, alloHSCT) after 1993, in first (CR1) or in second complete remission (CR2). Leukemia-free survival (LFS) at 5 years in CR1 was 69% for 149 patients autografted and 68% for 144 patients allografted, whereas in CR2, LFS was 51% in 195 autoHSCT and 59% in 137 alloHSCT recipients, respectively. In the group of autoHSCT for CR1 (n=149), higher relapse incidence (RI) was associated with shorter time from diagnosis to transplant (47 years), whereas for CR2, longer time from diagnosis to transplant (>18 months) was associated with increased LFS and decreased RI. In the alloHSCT group for CR1 (n=144), age (

Original languageEnglish
Pages (from-to)461-469
Number of pages9
JournalBone Marrow Transplantation
Volume39
Issue number8
DOIs
Publication statusPublished - Apr 2007

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Sanz, M. A., Labopin, M., Gorin, N. C., de la Rubia, J., Arcese, W., Meloni, G., Bacigalupo, A., Alessandrino, P., Carreras, E., Iriondo, A., Novitzky, N., Jacobs, P., Bandini, G., Lo-Coco, F., Frassoni, F., & Rocha, V. (2007). Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: A survey of the European Cooperative Group for Blood and Marrow Transplantation. Bone Marrow Transplantation, 39(8), 461-469. https://doi.org/10.1038/sj.bmt.1705620