Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

C Chabannon, J Kubal, A Bondanza, Francesco Dazzi, P Pedrazzoli, A Toubert, Annalisa Ruggeri, K Fleischhauer, C Bonini

Research output: Contribution to journalArticlepeer-review

Abstract

Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation. Copyright © 2018, American Association for the Advancement of Science.
Original languageEnglish
Article numberaap9630
JournalScience Translational Medicine
Volume10
Issue number436
DOIs
Publication statusPublished - 2018

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