Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Christian Chabannon; Jurgen Kuball; Attilio Bondanza; Francesco Dazzi; Paolo Pedrazzoli; Antoine Toubert; Annalisa Ruggeri; Katharina Fleischhauer; Chiara Bonini

doi:10.1126/scitranslmed.aap9630

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Christian Chabannon, Jurgen Kuball, Attilio Bondanza, Francesco Dazzi, Paolo Pedrazzoli, Antoine Toubert, Annalisa Ruggeri, Katharina Fleischhauer, Chiara Bonini

Research output: Contribution to journal › Review article › peer-review

Abstract

Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.

Original language	English
Journal	Science Translational Medicine
Volume	10
Issue number	436
DOIs	https://doi.org/10.1126/scitranslmed.aap9630
Publication status	Published - Apr 11 2018

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Hematopoietic stem cell transplantation in its 60s : A platform for cellular therapies. / Chabannon, Christian; Kuball, Jurgen; Bondanza, Attilio; Dazzi, Francesco; Pedrazzoli, Paolo; Toubert, Antoine; Ruggeri, Annalisa; Fleischhauer, Katharina; Bonini, Chiara.

In: Science Translational Medicine, Vol. 10, No. 436, 11.04.2018.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.",

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AU - Pedrazzoli, Paolo

AU - Toubert, Antoine

AU - Ruggeri, Annalisa

AU - Fleischhauer, Katharina

AU - Bonini, Chiara

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AB - Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.

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Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Abstract

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