Hemidystonia symptomatic of primary antiphospholipid syndrome in childhood

L. Angelini, V. Rumi, N. Nardocci, M. L. Combi, M. G. Bruzzone, G. Pellegrini

Research output: Contribution to journalArticlepeer-review


We report three children with hemidystonia in whom anti-cardiolipin (aCL) antibodies were demonstrated. Systemic lupus erythematosus was excluded on the basis of both clinical and serological criteria, and the diagnosis of primary antiphospholipid syndrome (PAPS) was made. In two cases, aCL antibodies could be causally related to a presumed immune mediated thrombotic event involving the basal ganglia as shown by magnetic resonance imaging (MRI). In the remaining patient the finding of white matter alteration on NMR might be due to cross-reactivity of anti-phospholipid (aPL) antibodies with cerebral phospholipids, resulting in demyelination. We suggest that PAPS must always be considered when isolated or recurrent focal cerebral ischaemia, and particularly hemidystonia, occur in childhood.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalMovement Disorders
Issue number3
Publication statusPublished - 1993


  • Antibodies
  • Antiphospholipid
  • Cerebrovascular disorders
  • Childhood
  • Hemidystonia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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