Hemochromatosis-induced bipolar disorder: A case report

Daniele Serata, Antonio Del Casale, Chiara Rapinesi, Iginia Mancinelli, Pieritalo Pompili, Giorgio D. Kotzalidis, Laura Aimati, Valeria Savoja, Gabriele Sani, Maurizio Simmaco, Roberto Tatarelli, Paolo Girardi

Research output: Contribution to journalArticlepeer-review


Objective: A patient presenting with. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, bipolar disorder was found to be affected by high iron hemochromatosis. This prompted us to explore the relation between bipolar disorder and iron overload. Method: We report the case and review the peer-reviewed literature focusing on mood symptoms in patients with hemochromatosis or iron overload. Animal studies of brain effects of iron overload are summarized. High iron hemochromatosis was confirmed by genetic testing, and treatment was instituted to address iron overload. Results: Patient's bipolar symptoms completely subsided after phlebotomic reduction of iron overload. Conclusion: Clinicians should explore the possibility of iron overload and seek genetic confirmation of hemochromatosis in resistant bipolar disorder to avoid unnecessary medication.

Original languageEnglish
JournalGeneral Hospital Psychiatry
Issue number1
Publication statusPublished - Jan 2012


  • Bipolar disorder
  • Comorbidity
  • Drug-refractory conditions
  • Genetics
  • Hemochromatosis
  • Psycho-organic syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Hemochromatosis-induced bipolar disorder: A case report'. Together they form a unique fingerprint.

Cite this