Hemodialysis without anticoagulants: Efficiency and hemostatic aspects

S. Casati, M. Moia, G. Graziani, A. Cantaluppi, A. Citterio, P. M. Mannucci, C. Ponticelli

Research output: Contribution to journalArticlepeer-review


In 29 patients with high risk of bleeding, 111 hemodialyses have been performed without heparin (WHD) or other anticoagulants. The same patients were switched to low dose heparin dialysis (LDHD) as soon as the bleeding risk had ceased. The dialyzer had to be changed in 11 and the drip chamber in 20 WHDs because of partial clotting. This phenomenon did not occur during LDHD. The comparative efficiencies of the two techniques were evaluated by measuring the urea and creatinine clearances of the dialyzers. No significant difference between LDHD and WHD clearances was observed. In 7 of 29 patients, hemostasis variables were studied before, during and after both modes of treatment. Fibrinogen, platelet count, antithrombin III and prothrombin time did not differ with the different dialysis procedures. During dialysis, platelet factor 4 (PF4) levels were significantly higher than baseline value (P

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalClinical Nephrology
Issue number2
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Hemodialysis without anticoagulants: Efficiency and hemostatic aspects'. Together they form a unique fingerprint.

Cite this