Hemodilution reduces clinic and ambulatory blood pressure in polycythemic patients

Giovanni Bertinieri, Gianfranco Parati, Luisa Ulian, Cinzia Santucciu, Paolo Massaro, Roberto Cosentini, Giuseppe Torgano, Alberto Morganti, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Limited information is available for humans on whether blood viscosity affects total peripheral resistance and, hence, blood pressure. Our study was aimed at assessing the effects of acute changes in blood viscosity on both clinic and 24-hour ambulatory blood pressure (BP) values. In 22 normotensive and hypertensive patients with polycythemia, clinic and 24-hour ambulatory BPs were measured before and 7 to 10 days after isovolumic hemodilution; this was performed through the withdrawal of 400 to 700 mL of blood, with concomitant infusion of an equivalent volume of saline-albumin solution. Hematocrit, plasma renin activity, plasma endothelin-1, fight atrial diameter (echocardiography), and blood viscosity were measured under both conditions. Plasma renin activity and right atrial diameter were used as indirect markers of blood volume changes. Plasma endothelin-1 was used to obtain information on a vasomotor substance possibly stimulated by our intervention, which could counteract vasomotor effects. Isovolumic hemodilution reduced hematocrit from 0.53±0.05 to 0.49±0.05 (P

Original languageEnglish
Pages (from-to)848-853
Number of pages6
JournalHypertension
Volume31
Issue number3
Publication statusPublished - Mar 1998

Keywords

  • Blood pressure monitoring, ambulatory
  • Blood viscosity
  • Hemodilution
  • Hemorheology

ASJC Scopus subject areas

  • Internal Medicine

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