Hemodynamic and anatomic variations require an adaptable approach during intra-arterial chemotherapy for intraocular retinoblastoma

Alternative routes, strategies, and follow-up

E. Bertelli, S. Leonini, D. Galimberti, S. Moretti, R. Tinturini, T. Hadjistilianou, S. De Francesco, D. G. Romano, I. M. Vallone, S. Cioni, Gennari, P. Galluzzi, I. Grazzini, S. Rossi, S. Bracco

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies. MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6-82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery. RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70% of them through the ophthalmic artery and 16.29% via the external carotid artery. In 24.52% of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern. CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.

Original languageEnglish
Pages (from-to)1289-1295
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

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Anatomic Variation
Retinoblastoma
Ophthalmic Artery
External Carotid Artery
Hemodynamics
Drug Therapy
Pharmaceutical Preparations
Retrospective Studies
Safety

Keywords

  • ECA=external carotid artery
  • FPEC=fixed pattern through the ECA
  • FPO=fixed pattern through the OA
  • IAC=intra-arterial chemotherapy
  • MMA=middle meningeal artery
  • OA=ophthalmic artery
  • VP=variable pattern

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Hemodynamic and anatomic variations require an adaptable approach during intra-arterial chemotherapy for intraocular retinoblastoma : Alternative routes, strategies, and follow-up. / Bertelli, E.; Leonini, S.; Galimberti, D.; Moretti, S.; Tinturini, R.; Hadjistilianou, T.; De Francesco, S.; Romano, D. G.; Vallone, I. M.; Cioni, S.; Gennari; Galluzzi, P.; Grazzini, I.; Rossi, S.; Bracco, S.

In: American Journal of Neuroradiology, Vol. 37, No. 7, 01.07.2016, p. 1289-1295.

Research output: Contribution to journalArticle

Bertelli, E, Leonini, S, Galimberti, D, Moretti, S, Tinturini, R, Hadjistilianou, T, De Francesco, S, Romano, DG, Vallone, IM, Cioni, S, Gennari, Galluzzi, P, Grazzini, I, Rossi, S & Bracco, S 2016, 'Hemodynamic and anatomic variations require an adaptable approach during intra-arterial chemotherapy for intraocular retinoblastoma: Alternative routes, strategies, and follow-up', American Journal of Neuroradiology, vol. 37, no. 7, pp. 1289-1295. https://doi.org/10.3174/ajnr.A4741
Bertelli, E. ; Leonini, S. ; Galimberti, D. ; Moretti, S. ; Tinturini, R. ; Hadjistilianou, T. ; De Francesco, S. ; Romano, D. G. ; Vallone, I. M. ; Cioni, S. ; Gennari ; Galluzzi, P. ; Grazzini, I. ; Rossi, S. ; Bracco, S. / Hemodynamic and anatomic variations require an adaptable approach during intra-arterial chemotherapy for intraocular retinoblastoma : Alternative routes, strategies, and follow-up. In: American Journal of Neuroradiology. 2016 ; Vol. 37, No. 7. pp. 1289-1295.
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abstract = "BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies. MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6-82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery. RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70{\%} of them through the ophthalmic artery and 16.29{\%} via the external carotid artery. In 24.52{\%} of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern. CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.",
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T2 - Alternative routes, strategies, and follow-up

AU - Bertelli, E.

AU - Leonini, S.

AU - Galimberti, D.

AU - Moretti, S.

AU - Tinturini, R.

AU - Hadjistilianou, T.

AU - De Francesco, S.

AU - Romano, D. G.

AU - Vallone, I. M.

AU - Cioni, S.

AU - Gennari,

AU - Galluzzi, P.

AU - Grazzini, I.

AU - Rossi, S.

AU - Bracco, S.

PY - 2016/7/1

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N2 - BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies. MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6-82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery. RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70% of them through the ophthalmic artery and 16.29% via the external carotid artery. In 24.52% of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern. CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.

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KW - FPO=fixed pattern through the OA

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KW - VP=variable pattern

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