Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals

Paolo Castiglioni, Gianfranco Parati, Davide Lazzeroni, Matteo Bini, Andrea Faini, Lorenzo Brambilla, Valerio Brambilla, Paolo Coruzzi

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BACKGROUND: Even if sodium sensitivity represents a risk factor at any blood pressure (BP) level, limited evidence is available that it may influence cardiovascular control in normotensives, particularly in white individuals. Therefore, the aim of the study was to investigate whether sodium sensitivity alters hemodynamic or autonomic responses to salt in normotensives.METHODS AND RESULTS: We evaluated the Sodium-Sensitivity Index (SS-Index) in 71 white normotensives after 5 days of high- and low-sodium diets. We measured BP continuously at the end of each period, estimating hemodynamic indices from BP waveform analysis, and autonomic indices from heart rate (HR) and BP variability. According to the SS-Index distribution, we defined 1 sodium-sensitive group (SS, with SS-Index >15 mm Hg/[mmol·day]), 1 sodium-resistant group, (unresponsive to sodium load with -15≤ SS-Index ≤+15), and 1 inverse sodium-sensitive group, responsive to sodium by decreasing BP, with SS-Index
Original languageEnglish
JournalJournal of the American Heart Association
Issue number8
Publication statusPublished - Aug 8 2016


  • Journal Article


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