Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals

Paolo Castiglioni, Gianfranco Parati, Davide Lazzeroni, Matteo Bini, Andrea Faini, Lorenzo Brambilla, Valerio Brambilla, Paolo Coruzzi

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Even if sodium sensitivity represents a risk factor at any blood pressure (BP) level, limited evidence is available that it may influence cardiovascular control in normotensives, particularly in white individuals. Therefore, the aim of the study was to investigate whether sodium sensitivity alters hemodynamic or autonomic responses to salt in normotensives.METHODS AND RESULTS: We evaluated the Sodium-Sensitivity Index (SS-Index) in 71 white normotensives after 5 days of high- and low-sodium diets. We measured BP continuously at the end of each period, estimating hemodynamic indices from BP waveform analysis, and autonomic indices from heart rate (HR) and BP variability. According to the SS-Index distribution, we defined 1 sodium-sensitive group (SS, with SS-Index >15 mm Hg/[mmol·day]), 1 sodium-resistant group, (unresponsive to sodium load with -15≤ SS-Index ≤+15), and 1 inverse sodium-sensitive group, responsive to sodium by decreasing BP, with SS-Index
Original languageEnglish
JournalJournal of the American Heart Association
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 8 2016

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Salts
Hemodynamics
Sodium
Blood Pressure
Sodium-Restricted Diet
Heart Rate

Keywords

  • Journal Article

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Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals. / Castiglioni, Paolo; Parati, Gianfranco; Lazzeroni, Davide; Bini, Matteo; Faini, Andrea; Brambilla, Lorenzo; Brambilla, Valerio; Coruzzi, Paolo.

In: Journal of the American Heart Association, Vol. 5, No. 8, 08.08.2016.

Research output: Contribution to journalArticle

Castiglioni, Paolo ; Parati, Gianfranco ; Lazzeroni, Davide ; Bini, Matteo ; Faini, Andrea ; Brambilla, Lorenzo ; Brambilla, Valerio ; Coruzzi, Paolo. / Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals. In: Journal of the American Heart Association. 2016 ; Vol. 5, No. 8.
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T1 - Hemodynamic and Autonomic Response to Different Salt Intakes in Normotensive Individuals

AU - Castiglioni, Paolo

AU - Parati, Gianfranco

AU - Lazzeroni, Davide

AU - Bini, Matteo

AU - Faini, Andrea

AU - Brambilla, Lorenzo

AU - Brambilla, Valerio

AU - Coruzzi, Paolo

N1 - © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

PY - 2016/8/8

Y1 - 2016/8/8

N2 - BACKGROUND: Even if sodium sensitivity represents a risk factor at any blood pressure (BP) level, limited evidence is available that it may influence cardiovascular control in normotensives, particularly in white individuals. Therefore, the aim of the study was to investigate whether sodium sensitivity alters hemodynamic or autonomic responses to salt in normotensives.METHODS AND RESULTS: We evaluated the Sodium-Sensitivity Index (SS-Index) in 71 white normotensives after 5 days of high- and low-sodium diets. We measured BP continuously at the end of each period, estimating hemodynamic indices from BP waveform analysis, and autonomic indices from heart rate (HR) and BP variability. According to the SS-Index distribution, we defined 1 sodium-sensitive group (SS, with SS-Index >15 mm Hg/[mmol·day]), 1 sodium-resistant group, (unresponsive to sodium load with -15≤ SS-Index ≤+15), and 1 inverse sodium-sensitive group, responsive to sodium by decreasing BP, with SS-Index

AB - BACKGROUND: Even if sodium sensitivity represents a risk factor at any blood pressure (BP) level, limited evidence is available that it may influence cardiovascular control in normotensives, particularly in white individuals. Therefore, the aim of the study was to investigate whether sodium sensitivity alters hemodynamic or autonomic responses to salt in normotensives.METHODS AND RESULTS: We evaluated the Sodium-Sensitivity Index (SS-Index) in 71 white normotensives after 5 days of high- and low-sodium diets. We measured BP continuously at the end of each period, estimating hemodynamic indices from BP waveform analysis, and autonomic indices from heart rate (HR) and BP variability. According to the SS-Index distribution, we defined 1 sodium-sensitive group (SS, with SS-Index >15 mm Hg/[mmol·day]), 1 sodium-resistant group, (unresponsive to sodium load with -15≤ SS-Index ≤+15), and 1 inverse sodium-sensitive group, responsive to sodium by decreasing BP, with SS-Index

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