Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study

E. Visani, L. Canafoglia, I. Gilioli, D. Rossi Sebastiano, V. E. Contarino, D. Duran, F. Panzica, R. Cubeddu, D. Contini, L. Zucchelli, L. Spinelli, M. Caffini, E. Molteni, A. M. Bianchi, S. Cerutti, S. Franceschetti, A. Torricelli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Multimodal human brain mapping has been proposed as an integrated approach capable of improving the recognition of the cortical correlates of specific neurological functions. We used simultaneous EEG-fMRI (functional magnetic resonance imaging) and EEG-TD-fNIRS (time domain functional near-infrared spectroscopy) recordings to compare different hemodynamic methods with changes in EEG in ten patients with progressive myoclonic epilepsy and 12 healthy controls. We evaluated O2Hb, HHb and Blood oxygen level-dependent (BOLD) changes and event-related desynchronization/synchronization (ERD/ERS) in the α and β bands of all of the subjects while they performed a simple motor task. The general linear model was used to obtain comparable fMRI and TD-fNIRS activation maps. We also analyzed cortical thickness in order to evaluate any structural changes. In the patients, the TD-NIRS and fMRI data significantly correlated and showed a significant lessening of the increase in O2Hb and the decrease in BOLD. The post-movement β rebound was minimal or absent in patients. Cortical thickness was moderately reduced in the motor area of the patients and correlated with the reduction in the hemodynamic signals. The fMRI and TD-NIRS results were consistent, significantly correlated and showed smaller hemodynamic changes in the patients. This finding may be partially attributable to mild cortical thickening. However, cortical hyperexcitability, which is known to generate myoclonic jerks and probably accounts for the lack of EEG β-ERS, did not reflect any increased energy requirement. We hypothesize that this is due to a loss of inhibitory neuronal components that typically fire at high frequencies.

Original languageEnglish
Pages (from-to)915-925
Number of pages11
JournalBrain Topography
Volume28
Issue number6
DOIs
Publication statusPublished - Sep 25 2014

Fingerprint

Myoclonus
Electroencephalography
Hand
Hemodynamics
Magnetic Resonance Imaging
Progressive Myoclonic Epilepsy
Oxygen
Brain Mapping
Near-Infrared Spectroscopy
Motor Cortex
Linear Models

Keywords

  • EEG-fMRI
  • Multimodal mapping
  • Myoclonus
  • Time domain fNIRS

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study. / Visani, E.; Canafoglia, L.; Gilioli, I.; Sebastiano, D. Rossi; Contarino, V. E.; Duran, D.; Panzica, F.; Cubeddu, R.; Contini, D.; Zucchelli, L.; Spinelli, L.; Caffini, M.; Molteni, E.; Bianchi, A. M.; Cerutti, S.; Franceschetti, S.; Torricelli, A.

In: Brain Topography, Vol. 28, No. 6, 25.09.2014, p. 915-925.

Research output: Contribution to journalArticle

Visani, E. ; Canafoglia, L. ; Gilioli, I. ; Sebastiano, D. Rossi ; Contarino, V. E. ; Duran, D. ; Panzica, F. ; Cubeddu, R. ; Contini, D. ; Zucchelli, L. ; Spinelli, L. ; Caffini, M. ; Molteni, E. ; Bianchi, A. M. ; Cerutti, S. ; Franceschetti, S. ; Torricelli, A. / Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study. In: Brain Topography. 2014 ; Vol. 28, No. 6. pp. 915-925.
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