TY - JOUR
T1 - Hemodynamic changes before acute heart failure episodes in patients with advanced systolic left ventricular dysfunction
AU - Ghio, Stefano
AU - Serio, Alessandra
AU - Mangiavacchi, Maurizio
AU - Kjellström, Barbro
AU - Valsecchi, Sergio
AU - Vicini, Ilaria
AU - Campana, Carlo
AU - Gasparini, Maurizio
AU - Gronda, Edoardo
AU - Tavazzi, Luigi
PY - 2008/8
Y1 - 2008/8
N2 - Aim: We sought to verify which changes in right ventricular pressures occur before acute heart failure (HF) in patients with advanced systolic left ventricular (LV) dysfunction. In patients with chronic HF, continuous hemodynamic monitoring by implantable devices may detect increases in pulmonary pressures before the onset of symptoms. METHODS: A device which allowed monitoring of right ventricular systolic (RVSP) and diastolic pressure (RVDP) and an estimate of pulmonary artery diastolic pressure (ePAD) was implanted in 10 patients with advanced LV systolic dysfunction and frequent cardiovascular hospitalizations [mean age 56.8 years; New York Heart Association (NYHA) classes IIIb-IV; LV ejection fraction at echocardiography 21 ± 2%]. RESULTS: During a follow-up period of 15 ± 12 months, 18 hospitalizations due to acute HF were recorded; 10 episodes were characterized by symptoms due to low-cardiac output (LCO) and eight episodes were characterized by symptoms due to pulmonary congestion. RVSP and ePAD increased before six hospitalizations and decreased before three episodes; RVDP increased before 10 hospitalizations and decreased before one. The extent of RVDP increase was 16 ± 24% before pulmonary congestion episodes and 29 ± 32% before LCO episodes. CONCLUSION: An increase in RVDP was the most frequent hemodynamic change detected by the implantable hemodynamic monitor before hospitalizations due to acute HF in patients having advanced systolic LV dysfunction.
AB - Aim: We sought to verify which changes in right ventricular pressures occur before acute heart failure (HF) in patients with advanced systolic left ventricular (LV) dysfunction. In patients with chronic HF, continuous hemodynamic monitoring by implantable devices may detect increases in pulmonary pressures before the onset of symptoms. METHODS: A device which allowed monitoring of right ventricular systolic (RVSP) and diastolic pressure (RVDP) and an estimate of pulmonary artery diastolic pressure (ePAD) was implanted in 10 patients with advanced LV systolic dysfunction and frequent cardiovascular hospitalizations [mean age 56.8 years; New York Heart Association (NYHA) classes IIIb-IV; LV ejection fraction at echocardiography 21 ± 2%]. RESULTS: During a follow-up period of 15 ± 12 months, 18 hospitalizations due to acute HF were recorded; 10 episodes were characterized by symptoms due to low-cardiac output (LCO) and eight episodes were characterized by symptoms due to pulmonary congestion. RVSP and ePAD increased before six hospitalizations and decreased before three episodes; RVDP increased before 10 hospitalizations and decreased before one. The extent of RVDP increase was 16 ± 24% before pulmonary congestion episodes and 29 ± 32% before LCO episodes. CONCLUSION: An increase in RVDP was the most frequent hemodynamic change detected by the implantable hemodynamic monitor before hospitalizations due to acute HF in patients having advanced systolic LV dysfunction.
KW - Heart failure
KW - Hospitalization
KW - Right heart hemodynamics
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U2 - 10.2459/JCM.0b013e3282f7301d
DO - 10.2459/JCM.0b013e3282f7301d
M3 - Article
C2 - 18607244
AN - SCOPUS:55949110058
VL - 9
SP - 799
EP - 804
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 8
ER -