Modificazioni emodinamiche durante infusione continua di dobutamina in pazienti candidati al trapianto di polmone. Gruppo Trapianto di Polmone.

Translated title of the contribution: Hemodynamic changes during continuous infusion with dobutamine in candidates for lung transplantation. Lung Transplantation Group

G. Della Rocca, F. Pierconti, C. D. Vizza, F. Pugliese, C. Coccia, L. Pompei, M. G. Costa, F. Venuta, E. A. Rendina, P. Pietropaoli, A. Gasparetto

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The aim of this study is to analyze the effects of dobutamine (DBT) on pulmonary and systemic hemodynamics and oxygenation in lung transplant candidates. METHODS: Forty-five patients (21M, 24F) to be introduced in waiting list for lung transplantation were studied (14 pulmonary fibrosis, 15 COPD, and 16 cystic fibrosis). They were studied awake, while spontaneously breathing in two different phases: baseline--O2 100%; DBT phase--O2 100% after 10 minutes of DBT continuous infusion (10 mcg/Kg/min). Blood gas samples and hemodynamic data were collected during right heart catheterization. Data were statistically analyzed with Student's "t" test and values for p <0.05 were considered as significant. RESULTS: During DBT phase, a significant increase of cardiac output with a decreasing in systemic and pulmonary vascular resistance was observed. Since the fall in pulmonary vascular resistance (PVRI) was not proportional to the increase of cardiac output, mean pulmonary artery pressure and transpulmonary gradient increased. The prevalent role of vascular recruitment as mechanism in PVRI reduction during DBT is supported by the concomitant fall in PaO2/FiO2. This strongly suggests a worsening of regional Va/Qc due to an increased perfusion of poorly ventilated areas. CONCLUSIONS: DBT reduces PVRI through a recruitment of vessels due to an increase of pulmonary flow. Dobutamine has a favorable hemodynamic effect in mild-to-moderate pulmonary hypertension in lung transplant candidates.

Translated title of the contributionHemodynamic changes during continuous infusion with dobutamine in candidates for lung transplantation. Lung Transplantation Group
Original languageItalian
Pages (from-to)785-790
Number of pages6
JournalMinerva Anestesiologica
Volume65
Issue number11
Publication statusPublished - Nov 1999

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Della Rocca, G., Pierconti, F., Vizza, C. D., Pugliese, F., Coccia, C., Pompei, L., Costa, M. G., Venuta, F., Rendina, E. A., Pietropaoli, P., & Gasparetto, A. (1999). Modificazioni emodinamiche durante infusione continua di dobutamina in pazienti candidati al trapianto di polmone. Gruppo Trapianto di Polmone. Minerva Anestesiologica, 65(11), 785-790.