Hemodynamic effects of cadralazine or chlorthalidone in verapamil-treated elderly hypertensives

R. Antonicelli, S. Savonnitto, P. F. Tomassini, C. Gambini, M. Sardina, E. Paciaroni

Research output: Contribution to journalArticle


Fourteen hypertensives aged > 66-77 years, whose diastolic blood pressure (DBP) was ≥ 95 mmHg at the end of 1-month treatment with verapamil 240 mg SR, took part in this clinical-hemodynamic study. Patients were randomized to add the long-acting hydralazine derivative, cadralazine, 10 mg once daily, or chlorthalidone 25 mg once daily for 1 month each, to their previous verapamil regimen, according to a double-blind crossover design. Echo-Doppler hemodynamics were performed before starting verapamil, 1 month after verapamil and then after each phase of the crossover study. A significant reduction in DBP both in supine and upright position was observed with both drugs, while the reduction in systolic blood pressure was not significant. Criteria for a satisfactory response were DBP ≤ 90 mmHg or a DBP reduction ≥ 10 mmHg: this goal was achieved in 9 patients with cadralazine, 9 patients with chlorthalidone, 5 patients with both. The hemodynamic study in responders showed that both cadralazine and chlorthalidone acted through a reduction of peripheral resistances without inducing reflex tachycardia. Thus, cadralazine and chlorthalidone represent a suitable second-step treatment in elderly hypertensives insufficiently controlled by verapamil monotherapy: both drugs act through a reduction in total peripheral resistance (TPR).

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Issue number4
Publication statusPublished - 1994


  • Cadralazine, chlorthalidone
  • Elderly hypertensives
  • Hemodynamics
  • Verapamil

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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