Hemodynamic effects of diuretics in patients with marked peripheral edema and mild hypertension

A. P. Niarchos, F. Magrini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hypertension develops in about 10% to 50% of patients with nephrosis or cirrhosis and peripheral edema, but the hemodynamic mechanism of the hypertension and its reversal by diuretic therapy has not been elucidated. In eight patients with marked edema and mild hypertension, diuretics (furosemide and spironolactone) decreased mean arterial pressure because of concurrent decrease in cardiac output and total peripheral resistance. Neither total blood volume nor plasma volume were decreased by the diuretics and the decrease in body weight was therefore attributed to the decrease in interstitial fluid volume. This, in turn, resulted in increased venous capacitance (as can be judged from the diuretic-induced decrease in the ratio of cardiopulmonary blood volume/total blood volume).

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number3
Publication statusPublished - 1982

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Diuretics
Edema
Blood Volume
Hemodynamics
Hypertension
Nephrosis
Spironolactone
Plasma Volume
Extracellular Fluid
Furosemide
Cardiac Output
Vascular Resistance
Arterial Pressure
Fibrosis
Body Weight
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hemodynamic effects of diuretics in patients with marked peripheral edema and mild hypertension. / Niarchos, A. P.; Magrini, F.

In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 3, 1982, p. 370-376.

Research output: Contribution to journalArticle

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