Hemodynamic effects of diuretics in patients with marked peripheral edema and mild hypertension

A. P. Niarchos, F. Magrini

Research output: Contribution to journalArticlepeer-review

Abstract

Hypertension develops in about 10% to 50% of patients with nephrosis or cirrhosis and peripheral edema, but the hemodynamic mechanism of the hypertension and its reversal by diuretic therapy has not been elucidated. In eight patients with marked edema and mild hypertension, diuretics (furosemide and spironolactone) decreased mean arterial pressure because of concurrent decrease in cardiac output and total peripheral resistance. Neither total blood volume nor plasma volume were decreased by the diuretics and the decrease in body weight was therefore attributed to the decrease in interstitial fluid volume. This, in turn, resulted in increased venous capacitance (as can be judged from the diuretic-induced decrease in the ratio of cardiopulmonary blood volume/total blood volume).

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pharmacology

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