TY - JOUR
T1 - Hemodynamic effects of MF 10058, a new cardioselective muscarinic M2 receptor antagonist, in conscious dogs
AU - Lamperti, Giuseppina
AU - Champeroux, Pascal
AU - Martel, Eric
AU - Colibretti, Maria Luisa
AU - Santoro, Luigi
AU - Imbimbo, Bruno P.
PY - 2000/10/6
Y1 - 2000/10/6
N2 - The 5-{4-[4-(diethylamino)butyl]-1-piperidinyl}acetyl-5H-dibenz[b,f]-azepine (MF 10058) is a new potent and selective muscarinic M2 receptor antagonist. The hemodynamic effects of MF 10058 were investigated in conscious freely moving dogs. Placebo and three doses of MF 10058 (2, 4 and 8 mg/kg) were orally administered according to a randomised four-way crossover design. Heart rate, cardiac conduction times, systolic and diastolic blood pressure were telemetrically recorded for 12-24 h after dosing. After placebo administration, a consistent reduction over time in heart rate was observed during the night-time period (-15%, P=0.019). MF 10058 administration antagonised the nocturnal bradycardia and shortened QT interval. The effect of the drug reached statistically significance, compared to placebo, with the highest dose of 8 mg/kg (+19% on heart rate, P=0.013; -4% on QT interval, P=0.049). The effect on heart rate lasted for the entire 24-h observation period (+16%, P=0.030). Nocturnal systolic and diastolic blood pressure were not significantly affected by MF 10058. No other signs of peripheral or central cholinergic block were observed at any dose. The results of this study demonstrated that oral administration of MF 10058 produces long-lasting hemodynamic effects in the conscious dog. The drug has a therapeutic potential for the treatment of bradycardic disorders. Copyright (C) 2000 Elsevier Science B.V.
AB - The 5-{4-[4-(diethylamino)butyl]-1-piperidinyl}acetyl-5H-dibenz[b,f]-azepine (MF 10058) is a new potent and selective muscarinic M2 receptor antagonist. The hemodynamic effects of MF 10058 were investigated in conscious freely moving dogs. Placebo and three doses of MF 10058 (2, 4 and 8 mg/kg) were orally administered according to a randomised four-way crossover design. Heart rate, cardiac conduction times, systolic and diastolic blood pressure were telemetrically recorded for 12-24 h after dosing. After placebo administration, a consistent reduction over time in heart rate was observed during the night-time period (-15%, P=0.019). MF 10058 administration antagonised the nocturnal bradycardia and shortened QT interval. The effect of the drug reached statistically significance, compared to placebo, with the highest dose of 8 mg/kg (+19% on heart rate, P=0.013; -4% on QT interval, P=0.049). The effect on heart rate lasted for the entire 24-h observation period (+16%, P=0.030). Nocturnal systolic and diastolic blood pressure were not significantly affected by MF 10058. No other signs of peripheral or central cholinergic block were observed at any dose. The results of this study demonstrated that oral administration of MF 10058 produces long-lasting hemodynamic effects in the conscious dog. The drug has a therapeutic potential for the treatment of bradycardic disorders. Copyright (C) 2000 Elsevier Science B.V.
KW - Antibradycardic agent
KW - Bradycardia
KW - Cardioselective muscarinic receptor antagonist
KW - MF 10058
KW - Muscarinic M receptor antagonist
KW - Sick sinus syndrome
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U2 - 10.1016/S0014-2999(00)00611-7
DO - 10.1016/S0014-2999(00)00611-7
M3 - Article
C2 - 11011039
AN - SCOPUS:0034613232
VL - 406
SP - 93
EP - 98
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -