Hemodynamic effects of nitroglycerin

F. Fantini, R. P. Dabizzi, F. Franchi, A. Michelucci, L. Padeletti

Research output: Contribution to journalArticlepeer-review


The authors have studied the hemodynamic effects of sublingually administered nitroglycerin (NG). Obtained data indicate that the response to NG is time-dependent. A first phase, lasting about 2 minutes, is characterized by a reduction of total systemic resistance (TSR) and an increase of cardiac output (CO), without significant variations of left ventricular filling pressure (FP) and blood pressure (BP). A modest increase of heart rate (HR) is observed. The second phase is characterized by a reduced FP and later, after 5 minutes, of BP. Subsequently HR increases to a greater degree, CO decreases and TRS presents a variation toward control values.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Issue number11
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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