Abstract
It has been shown that apneic oxygenation can be safely performed for many days when metabolic carbon dioxide is removed by an extracorporeal membrane lung, and 100% oxygen is supplied directly into the trachea to keep the intrapulmonary pressure at 5 cm. H2O. The study was designed to find 'best intrapulmonary pressure (IP)', analogous to 'best PEEP' during continuous positive pressure ventilation. In the present study we have shown that when IP was progressively raised from 5 cm H2O to 20 cm H2O the PaO2 rose significantly due to progressive decrease in ̇Q(VA)/̇Q. A linear positive correlation was found between CO and ̇Q(VA)/̇Q. There was a negative correlation between ̇Q(VA)/̇Q and FRC. Total static lung compliance and FRC increased significantly at 15-20 cm H2O IP. There was no significant change in urinary flow, urea and creatinine clearances. We conclude that in apneic oxygenation a more 'optimal IP' is attained at an IP pressure of 20 cm H2O than at 5 cm H2O.
| Original language | English |
|---|---|
| Pages (from-to) | 249-253 |
| Number of pages | 5 |
| Journal | International Journal of Artificial Organs |
| Volume | 2 |
| Issue number | 5 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Biophysics
Cite this
Hemodynamic, mechanical and renal effects during 'apneic oxygenation' with extracorporeal carbon dioxide removal, at different levels of intrapulmonary pressure in lambs. / Gattinoni, L.; Iapichino, G.; Kolobow, T.
In: International Journal of Artificial Organs, Vol. 2, No. 5, 1979, p. 249-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemodynamic, mechanical and renal effects during 'apneic oxygenation' with extracorporeal carbon dioxide removal, at different levels of intrapulmonary pressure in lambs
AU - Gattinoni, L.
AU - Iapichino, G.
AU - Kolobow, T.
PY - 1979
Y1 - 1979
N2 - It has been shown that apneic oxygenation can be safely performed for many days when metabolic carbon dioxide is removed by an extracorporeal membrane lung, and 100% oxygen is supplied directly into the trachea to keep the intrapulmonary pressure at 5 cm. H2O. The study was designed to find 'best intrapulmonary pressure (IP)', analogous to 'best PEEP' during continuous positive pressure ventilation. In the present study we have shown that when IP was progressively raised from 5 cm H2O to 20 cm H2O the PaO2 rose significantly due to progressive decrease in ̇Q(VA)/̇Q. A linear positive correlation was found between CO and ̇Q(VA)/̇Q. There was a negative correlation between ̇Q(VA)/̇Q and FRC. Total static lung compliance and FRC increased significantly at 15-20 cm H2O IP. There was no significant change in urinary flow, urea and creatinine clearances. We conclude that in apneic oxygenation a more 'optimal IP' is attained at an IP pressure of 20 cm H2O than at 5 cm H2O.
AB - It has been shown that apneic oxygenation can be safely performed for many days when metabolic carbon dioxide is removed by an extracorporeal membrane lung, and 100% oxygen is supplied directly into the trachea to keep the intrapulmonary pressure at 5 cm. H2O. The study was designed to find 'best intrapulmonary pressure (IP)', analogous to 'best PEEP' during continuous positive pressure ventilation. In the present study we have shown that when IP was progressively raised from 5 cm H2O to 20 cm H2O the PaO2 rose significantly due to progressive decrease in ̇Q(VA)/̇Q. A linear positive correlation was found between CO and ̇Q(VA)/̇Q. There was a negative correlation between ̇Q(VA)/̇Q and FRC. Total static lung compliance and FRC increased significantly at 15-20 cm H2O IP. There was no significant change in urinary flow, urea and creatinine clearances. We conclude that in apneic oxygenation a more 'optimal IP' is attained at an IP pressure of 20 cm H2O than at 5 cm H2O.
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M3 - Article
C2 - 383627
AN - SCOPUS:0018682647
VL - 2
SP - 249
EP - 253
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 5
ER -