Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal - A comparison with continuous positive pressure ventilation

L. Gattinoni, A. Agostoni, G. Damia, D. Cantaluppi, C. Bernasconi, L. Tarenzi, A. Pelizzola, G. P. Rossi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Six lambs were anesthetized and connected in venouvenous mode to a Membrane Lung for Extracorporeal CO2 removal. The animals underwent several hours periods of continuous positive pressure ventilation (CPPV), at 5 cmH2O positive end expiratory pressure (PEEP), alternated with several hours periods of low frequency positive pressure ventilation (5 cmH2O PEEP, 2 b.p.m.) with extracorporeal CO2 removal (LFPPV-ECCO2R). During LFPPV-ECCO2R compared with CPPV, cardiac output increased by 26%, pulmonary vascular resistances and systemic vascular resistances decreased by 28% and 22% respectively. The renal function improved significantly during LFPPV-ECCO2R compared with CPPV, i.e. urinary flow, creatinine clearance and osmolar clearance increased by 50%, 37% and 52% respectively. In these experiments LFPPV-ECCO2R, a form of completely artificial ventilation, seems to prevent hemodynamic and renal complications of CPPV.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalIntensive Care Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 1980

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Positive-Pressure Respiration
Hemodynamics
Kidney
Vascular Resistance
Cardiac Output
Creatinine
Lung
Membranes

Keywords

  • apnea
  • artificial ventilation
  • extracorporeal circulation
  • hemodynamic
  • lung and end positive pressure ventilation
  • membrane lung
  • renal function

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal - A comparison with continuous positive pressure ventilation. / Gattinoni, L.; Agostoni, A.; Damia, G.; Cantaluppi, D.; Bernasconi, C.; Tarenzi, L.; Pelizzola, A.; Rossi, G. P.

In: Intensive Care Medicine, Vol. 6, No. 3, 1980, p. 155-161.

Research output: Contribution to journalArticle

Gattinoni, L. ; Agostoni, A. ; Damia, G. ; Cantaluppi, D. ; Bernasconi, C. ; Tarenzi, L. ; Pelizzola, A. ; Rossi, G. P. / Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal - A comparison with continuous positive pressure ventilation. In: Intensive Care Medicine. 1980 ; Vol. 6, No. 3. pp. 155-161.
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AU - Cantaluppi, D.

AU - Bernasconi, C.

AU - Tarenzi, L.

AU - Pelizzola, A.

AU - Rossi, G. P.

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