Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO2 removal - A comparison with continuous positive pressure ventilation

L. Gattinoni, A. Agostoni, G. Damia, D. Cantaluppi, C. Bernasconi, L. Tarenzi, A. Pelizzola, G. P. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Six lambs were anesthetized and connected in venouvenous mode to a Membrane Lung for Extracorporeal CO2 removal. The animals underwent several hours periods of continuous positive pressure ventilation (CPPV), at 5 cmH2O positive end expiratory pressure (PEEP), alternated with several hours periods of low frequency positive pressure ventilation (5 cmH2O PEEP, 2 b.p.m.) with extracorporeal CO2 removal (LFPPV-ECCO2R). During LFPPV-ECCO2R compared with CPPV, cardiac output increased by 26%, pulmonary vascular resistances and systemic vascular resistances decreased by 28% and 22% respectively. The renal function improved significantly during LFPPV-ECCO2R compared with CPPV, i.e. urinary flow, creatinine clearance and osmolar clearance increased by 50%, 37% and 52% respectively. In these experiments LFPPV-ECCO2R, a form of completely artificial ventilation, seems to prevent hemodynamic and renal complications of CPPV.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalIntensive Care Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 1980

Keywords

  • apnea
  • artificial ventilation
  • extracorporeal circulation
  • hemodynamic
  • lung and end positive pressure ventilation
  • membrane lung
  • renal function

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Hemodynamics and renal function during low frequency positive pressure ventilation with extracorporeal CO<sub>2</sub> removal - A comparison with continuous positive pressure ventilation'. Together they form a unique fingerprint.

Cite this