Hemoglobin levels and circulating blasts are two easily evaluable diagnostic parameters highly predictive of leukemic transformation in primary myelofibrosis

Angela Rago, Roberto Latagliata, Marco Montanaro, Enrico Montefusco, Alessandro Andriani, Sabrina Leonetti Crescenzi, Sergio Mecarocci, Francesca Spirito, Antonio Spadea, Umberto Recine, Laura Cicconi, Giuseppe Avvisati, Michele Cedrone, Massimo Breccia, Raffaele Porrini, Nicoletta Villivà, Cinzia De Gregoris, Giuliana Alimena, Enzo D'Arcangelo, Paola GuglielmelliFrancesco Lo-Coco, Alessandro Vannucchi, Giuseppe Cimino

Research output: Contribution to journalArticlepeer-review

Abstract

To predict leukemic transformation (LT), we evaluated easily detectable diagnostic parameters in 338 patients with primary myelofibrosis (PMF) followed in the Latium region (Italy) between 1981 and 2010. Forty patients (11.8%) progressed to leukemia, with a resulting 10-year leukemia-free survival (LFS) rates of 72%. Hb (

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalLeukemia Research
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Anemia
  • Circulating blasts
  • Leukaemic transformation
  • Leukemic transformation risk
  • Primary myelofibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

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