Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: The role of erythropoietic growth factors

F. Bellati, M. Pernice, N. Manci, I. Palaia, F. Tomao, C. Marchetti, M. A. Zullo, L. Muzii, R. Angioli, Pierluigi Benedeth Panici

Research output: Contribution to journalArticle

Abstract

Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice. Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice. Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease. Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions.

Original languageEnglish
Pages (from-to)722-729
Number of pages8
JournalAnnals of Oncology
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Blood transfusions
  • Erythropoietic growth factors
  • Locally advanced cervical cancer
  • Neo-adjuvant chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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