Anemia hemolítica causada por hemoglobina Evans en una familia argentina

Translated title of the contribution: Hemolytic anemia due to hemoglobin Evans in an Argentinean family

María I. Zanotto, Karina Calvo, Gabriel Schvartzman, Alejandra Deana, Nélida Noguera, Irma Bragós, Ángela Milani

Research output: Contribution to journalArticlepeer-review


Unstable hemoglobins are structural variants of the hemoglobin molecule, mostly originated by single amino-acid replacement in some globin chains. These changes affect molecule stability, leading to loss of solubility, precipitation, and cellular lysis. Patients carrying these unstable hemoglobins may present mild to severe chronic hemolytic anemia. Hemoglobin Evans is an unstable variant originated by replacement of valine with methionine at position 62 of the α-globin chain. We have identified this variant in a girl with an acute hemolytic crisis associated to pharyngitis, as well as in two of her family members. This is the third case of hemolytic anemia due to hemoglobin Evans reported in the literature.

Translated title of the contributionHemolytic anemia due to hemoglobin Evans in an Argentinean family
Original languageSpanish
JournalArchivos Argentinos de Pediatria
Issue number6
Publication statusPublished - Nov 2010


  • α -globin gene
  • Hemoglobin Evans
  • Unstable hemoglobin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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